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FLASH GENE
Symbol ZNF689 contributors: mct/npt/pgu - updated : 23-08-2012
HGNC name zinc finger protein 689
HGNC id 25173
Location 16p11.2      Physical location : 30.614.700 - 30.621.682
Synonym name
  • transcription-involved protein upregulated in HCC 1
  • zinc finger protein HIT-39
  • Synonym symbol(s) TIPUH1, FLJ90415, DKFZp762C173
    DNA
    TYPE functioning gene
    STRUCTURE 7.00 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 2724 56.9 500 - 2011 21624362
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumear   highly
    Reproductivemale systemtestis  highly
    cell lineage
    cell lines
    fluid/secretion lymph highly
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 12 zinc-finger domains
  • a Kruppel-associated box domain
  • HOMOLOGY
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • CATEGORY transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • having an oncogenic activity
  • may play a role in hepatocarcinogenesis by regulating transcription and/or RNA processing of growth control genes
  • blocks pro-apoptotic signaling by suppressing the BAK1/BAX/BID pathway, resulting in the progression of liver cancer and resistance to 5-fluorouracil
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with MID1 (KRAB-ZNF transcriptional repressor of MID1)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hepatocellular carcinomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    may be a promising chemotherapeutic target against liver cancer
    ANIMAL & CELL MODELS