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FLASH GENE
Symbol ZNF675 contributors: - updated : 30-11-2006
HGNC name zinc finger protein 675
HGNC id 0
Location 19p12      Physical location : 23.835.708 - 23.870.017
Synonym name TRAF6-inhibitory zinc finger protein
Synonym symbol(s) TBZF, TIZ
DNA
TYPE functioning gene
STRUCTURE 34.00 kb     4 Exon(s)
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
Reproductivefemale systembreastmammary gland highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
Muscular   moderately
cell lineage osteoclast precursor
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a C2H2 type zinc finger domain
  • HOMOLOGY
    interspecies homolog to chimpanzee ZNF675 (98.4 pc)
    Homologene
    FAMILY
    CATEGORY adaptor , signaling cytokine
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • modulating TRAF6 signaling pathway
  • inhibiting the osteoclastogenic activity and function of TRAF6 and TNFRSF11A
  • acting as a transcriptional repressor
  • CELLULAR PROCESS cell life, differentiation
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text
  • negative regulation of osteoclast differentiation
  • bone resorption
  • negative regulation of transcription
  • regulation of ossification
  • PATHWAY
    metabolism
    signaling signal transduction
  • I-kappaB kinase/NF-kappaB cascade
  • negative regulation of JNK cascade
  • a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS