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FLASH GENE

Symbol

ZNF668

contributors: mct - updated : 06-04-2013

HGNC name	zinc finger protein 668
HGNC id	25821

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	16p11.2      Physical location : 31.072.163 - 31.085.641

DNA

TYPE	functioning gene
STRUCTURE	13.48 kb     3 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_024706 3 - 2769 NP_078982 - 619 - 2011 21852383 NM_001172670 3 - 2396 NP_001166141 - 619 - 2011 21852383 NM_001172669 4 - 2510 NP_001166140 - 642 - 2011 21852383 NM_001172668 3 - 2865 NP_001166139 - 619 - 2011 21852383

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

tumor suppressor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleolus

basic FUNCTION	nucleolar protein that physically interacts with and regulates TP53 and its negative regulator MDM2
	novel breast tumor suppressor gene that functions in regulating TP53 stability

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

through MDM2 binding, ZNF668 regulated autoubiquitination of MDM2 and its ability to mediate TP53 ubiquitination and degradation

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS