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FLASH GENE
Symbol ZNF652 contributors: mct/npt - updated : 11-04-2012
HGNC name zinc finger protein 652
HGNC id 29147
Location 17q21.33      Physical location : 47.366.568 - 47.439.835
Synonym name related to rat zinc finger protein rkr2
Synonym symbol(s) KIAA0924, DKFZp781E2122
DNA
TYPE functioning gene
STRUCTURE 73.27 kb     6 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 11492 69 606 - 2008 18456661
6 - 11347 69 606 - 2008 18456661
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   highly
 thyroid   highly
Nervousbrain    
 spinal cord   highly
Reproductivefemale systembreastmammary gland highly
 male systemprostate   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • zinc finger motif
  • HOMOLOGY
    interspecies homolog to rattus zinc finger protein Rkr2
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • CBFA2T3-ZNF652-mediated HEB regulation may play an important role in hematopoiesis and myogenesis
  • CBFA2T3-ZNF652 corepressor complex regulates transcription of the E-box gene TCF12
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complex CBFA2T3-ZNF652
  • INTERACTION
    DNA DNA binding motif
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • interacting with CBFA2T3, to repress TCF12 expression, and in addition CBFA2T3 interacts with the TCF12 protein to inhibit its activator function
  • interacts with the ETO protein CBFA2T3 and has a role in the suppression of breast oncogenesis
  • strongly interacts with CBFA2T3 and this interaction occurs through the C-terminal 109 amino acids of ZNF652
  • specifically and functionally interacts with CBFA2T3 to repress transcription of genes involved in breast oncogenesis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    of both AR and ZNF652 in clinically organ-defined prostate cancer are associated with a statistically increased risk of relapse
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS