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FLASH GENE
Symbol ZNF638 contributors: mct - updated : 05-05-2012
HGNC name zinc finger protein 638
HGNC id 17894
Location 2p13.2      Physical location : 71.558.888 - 71.662.187
Synonym name
  • large DNA-binding protein
  • zinc finger, matrin-like
  • nuclear protein 220
  • cutaneous T-cell lymphoma-associated antigen se33-1
  • Synonym symbol(s) NP220, MGC26130, Zfp638, ZFML, DKFZp686P1231
    DNA
    TYPE functioning gene
    STRUCTURE 103.30 kb     28 Exon(s)
    MAPPING cloned Y linked N status provisional
    regionally located in the PARK3 region
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    28 - 6527 - 1978 - 2011 21602272
    28 - 6517 - 1978 - 2011 21602272
    - - 6842 - 1978 - 2011 21602272
    - - 6463 - 1957 - 2011 21602272
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three domains of homology with the acidic nuclear protein matrin 3
  • the second motif being homolog to the RNA recognition motif
  • a C terminus DNA-binding domain
  • a serine/arginine rich sequence
  • multiple conserved motifs that may suggest that ZNF638 could function as an adaptor molecule to assemble other proteins in a functional transcription complex
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm,nuclear bodies,coiled bodies (Cajal)
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text
  • diffusing in cytoplasm during mitosis
  • dDuring adipocyte differentiation, ZNF638 is driven by its RS domain to localize in nuclear speckles
  • basic FUNCTION
  • binding double stranded DNA fragment by recognizing clusters of cytidines
  • novel and early regulator of adipogenesis that works as a transcription cofactor of CEBPs
  • CELLULAR PROCESS nucleotide, chromatin organization
    nucleotide, replication
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA binding
    small molecule
    protein
  • physically interacts and transcriptionally cooperates with CCAAT/enhancer-binding protein (CEBPB and CEBPD)
  • induces PPARG expression through physical interaction and functional cooperation with CEBPs on the PPARG promoter
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS