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FLASH GENE
Symbol ZNF622 contributors: mct - updated : 23-08-2012
HGNC name zinc finger protein 622
HGNC id 30958
Location 5p15.1      Physical location : 16.451.628 - 16.465.894
Synonym symbol(s) ZPR9
DNA
TYPE functioning gene
STRUCTURE 14.27 kb     6 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 1710 - 477 - -
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemuteruscervix predominantly
Respiratoryrespiratory tractlarynx  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two U1-type zinc fingers
  • three zinc finger motifs
  • conjugated PhosphoP
    mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies ortholog to murine Zfp622
    Homologene
    FAMILY
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus,nucleolus
    text
  • the phosphorylation by MELK may redirect the protein to the nucleus
  • mainly localized in the cytoplasm, but its interacting partner MELK redirects the subcellular localization of ZNF622 from the cytoplasm to the nucleus through direct interaction
  • basic FUNCTION
  • may behave as an activator of the bound transcription factor MYBL2
  • involved in embryonic development
  • a potentially important role in MPK38-mediated signal transduction
  • playing an important role in modulation of the transactivation by B-MYB and cellular growth of neuroblastoma cells
  • functions as a novel positive regulator of MAP3K5
  • plays an important role in the regulation of the MAP3K5-mediated signaling pathway, in which it acts as a positive regulator of MAP3K5 by modulating complex formation between MAP3K5 and its negative regulators, TXN and 14-3-3, or its substrate MAP2K3
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text
  • embryonic development
  • PATHWAY
    metabolism
    signaling signal transduction
  • MPK38-mediated signal transduction
  • a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • MYBL2
  • MELK
  • physically interact with MAP3K5
  • cell & other
    REGULATION
    Other the phosphorylation by MELK may redirect the protein to the nucleus
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS