Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ZNF582 contributors: mct - updated : 01-12-2021
HGNC name zinc finger protein 582
HGNC id 26421
Location 19q13.43      Physical location : 56.894.647 - 56.904.889
Synonym symbol(s) FLJ30927
DNA
TYPE functioning gene
STRUCTURE 10.83 kb     5 Exon(s)
MAPPING cloned Y linked Y status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 2839 - 517 - 2020 33038291
5 - 3061 - 517 - 2020 33038291
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY tumor suppressor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • acts as a tumor suppressor gene in NPC by regulating the transcription and expression of NECTIN3 and NRXN3
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • both NECTIN3 and NRXN3 were identified as functional targets of ZNF582, and the restoration or abrogation of these genes reversed the tumor suppressor effect of ZNF582 in nasopharyngeal carcinoma (NPC) metastasis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    by promoter hypermethylation in nasopharyngeal carcinoma (NPC)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • hypermethylated PAX1 and ZNF582 can sufficiently act as biomarkers to reflect the severity or progression of oral squamous cell carcinoma (OSCC)
  • Therapy target
    ANIMAL & CELL MODELS