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FLASH GENE
Symbol ZNF569 contributors: - updated : 19-09-2007
HGNC name zinc finger protein 569
HGNC id 24737
Location 19q13.12      Physical location : 37.902.061 - 37.958.339
Synonym symbol(s) ZNF, ZAP1, FLJ32053
DNA
TYPE functioning gene
STRUCTURE 56.00 kb     6 Exon(s)
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth   moderately
Endocrineneuroendocrinepituitary  highly
Lymphoid/Immunethymus   moderately
Nervousbrain   moderately
Reproductivemale systemtestis  moderately
Respiratoryrespiratory tracttrachea  moderately
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, fetal, pregnancy
Text embryonic tissue
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • eighteen C2H2-type zinc-finger
  • a KRAB domain
    • HOMOLOGY
    interspecies homolog to rattus Zfp74 (85.29 pc)
    homolog to chimpanzee ZFP569 (100.00 pc)
    homolog to murine Zfp74 (84.09 pc)
    Homologene
    FAMILY krueppel C2H2-type zinc-finger protein family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • acting as a transcriptional repressor, suppressing MAPK signaling pathway
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS