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FLASH GENE

Symbol

ZNF541

contributors: npt - updated : 19-05-2009

HGNC name	zinc finger protein 541
HGNC id	25294

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19q13.32      Physical location : 48.023.947 - 48.059.113
Synonym symbol(s)	DKFZp434I1930, MGC119518, MGC119519, MGC119521

DNA

TYPE	functioning gene
STRUCTURE	24.57 kb     13 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed ZNF541 13 - 4632 148 1365 - Sjöblom (2006)

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Skin/Tegument skin         Urinary kidney       lowly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two sant domains
	C2H2-type zinc fingers

HOMOLOGY

Homologene

FAMILY

n-cor nuclear receptor corepressors family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION

mediating the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

ZNF541/KCTD19 signaling complex, acting as a key transcription regulator, plays an indispensable role in male fertility by regulating pachytene progression

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	Zn2+

protein	association of KCTD19 with zinc finger protein 541 (ZNF541) and histone deacetylase 1 (HDAC1)
	ZNF541 binds to and activates the expression of genes involved in meiosis and post-meiosis including KCTD19

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS