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FLASH GENE
Symbol ZNF496 contributors: - updated : 01-09-2005
HGNC name zinc finger protein 496
HGNC id 23713
Location 1q44      Physical location : 247.463.622 - 247.495.045
Synonym symbol(s) MGC15548, NIZP1
DNA
TYPE functioning gene
STRUCTURE 31.00 kb     11 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveintestinesmall intestine  highly
Reproductivefemale systemuteruscervix highly
Respiratoryrespiratory tractlarynx  predominantly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four consensus C2H2-type zinc fingers preceded by a unique finger derivative, referred to herein as the C2HR motif, and functioning as a docking site for NSD1
  • one KRAB domain
  • one SCAN box domain
  • HOMOLOGY
    Homologene
    FAMILY krueppel C2H2-type zinc-finger protein family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in the regulation of transcription, DNA-dependent
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    Zn2+
    protein interacting with NSD1, to mediate protein-protein interaction with the cysteine-rich (C5HCH) domain of NSD1 in a Zn(II)-dependent fashion
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS