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FLASH GENE
Symbol ZNF492 contributors: mct - updated : 26-03-2008
HGNC name zinc finger protein 492
HGNC id 23707
Location 19p12      Physical location : 22.817.125 - 22.850.472
Synonym symbol(s) KIAA1473, MGC129633, MGC148019
DNA
TYPE functioning gene
STRUCTURE 33.00 kb     4 Exon(s)
MAPPING cloned   linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis   
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a truncated N-terminus and lacks the usual Krüppel-associated box-A (KRAB-A) while KRAB-B remains intact
  • a KRAB domain
  • 12 C2H2 zinc-fingers in tandem arrangement
  • HOMOLOGY
    interspecies homolog to chimpanzee LOC468784
    Homologene
    FAMILY krueppel C2H2-type zinc-finger protein family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in transcriptional regulation
  • acting as moderate transcriptional factor for RPE65 gene upregulation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    Zn2+
    protein regulator of RPE65
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS