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FLASH GENE
Symbol ZNF473 contributors: mct/npt - updated : 03-05-2008
HGNC name zinc finger protein 473
HGNC id 23239
Location 19q13.33      Physical location : 50.529.211 - 50.552.029
Synonym name zinc finger protein ZFP100 homolog
Synonym symbol(s) KIAA1141, ZFP100, ZN473, DKFZP434N043
DNA
TYPE functioning gene
STRUCTURE 22.00 kb     5 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
text variants 1 and 2 encode the same protein
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 4711 100.2 871 - Wagner (2006)
5 - 4589 100.2 871 - Wagner (2006)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
 nerve   highly
Reproductivemale systemtestis  highly
Visualeye    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 18 C2H2-type zinc fingers (region encompassing fingers 2-6 is sufficient to maintain Cajal bodies localization and required for maximal binding to a 20 AA region of LSM11) (Wagner 2006)
  • one KRAB domain
  • HOMOLOGY
    interspecies homolog to rattus LOC292884
    Homologene
    FAMILY
  • Krueppel C2H2-type zinc finger protein family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in pre-mRNA processing by associating with U7snRNP and interacting with SLBP/pre-mRNA complex
  • associated with U7 snRNP and interacts with the stem-loop binding protein in the histone pre-mRNP to stimulate 3'-end processing
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of U7 snRNP that interacts with the SLBP/pre-mRNA complex
  • INTERACTION
    DNA
    RNA interacts with U7snRNP
    small molecule metal binding,
  • ion Zn2+
  • protein
  • interacts with SLBP/pre-mRNA complex
  • ; interacting with LSM11 (Azzouz 2005)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    increasing the amount of ZNF473 increases histone pre-mRNA processing but has no effect on U7 snRNP levels (Wagner 2006)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS