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Symbol ZNF468 contributors: mct - updated : 09-06-2020
HGNC name zinc finger protein 468
HGNC id 33105
Location 19q13.41      Physical location : 53.341.785 - 53.360.902
Synonym symbol(s) DKFZp781B1474, DKFZp781N07108
DNA
TYPE functioning gene
STRUCTURE 19.61 kb     4 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 4405 - 522 - 2005 16144304
  • ZNF468.1
  • 5 - 4024 - 469 widely expressed in tissues, except in heart and brain 2005 16144304
  • has one exon more, between the third and fourth exon
  • does not have the KRAB domain
  • 5 - 4523 - 127 - 2005 16144304
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemplacenta  highly
    Respiratoryrespiratory tracttrachea  highly
    Urinarykidney   predominantly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • well-conserved Kruppel-associated box (KRAB)at the N-terminus
  • 11 C2H2-type zinc finger motifs at C-terminus
  • HOMOLOGY
    Homologene
    FAMILY krueppel C2H2-type zinc-finger protein family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS