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FLASH GENE
Symbol ZNF467 contributors: mct - updated : 08-09-2011
HGNC name zinc finger protein 467
HGNC id 23154
Location 7q36.1      Physical location : 149.461.452 - 149.470.295
Synonym symbol(s) EZI, Zfp467
DNA
TYPE functioning gene
STRUCTURE 8.84 kb     5 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 2295 - 595 - 2002 12426389
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus   predominantly
Respiratorylung   highly
Urinarykidney   moderately
Visualeye   moderately
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal domain is necessary for its nuclear export
  • twelve C2H2-type zinc fingers
    • HOMOLOGY
    interspecies ortholog to murine Zfp467
    Homologene
    FAMILY Krüppel-like family of transcription factors (KLF)
    CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • localizes predominantly in the nucleus
  • nucleocytoplasmic shuttling mechanism that is mediated by importin-7-dependent nuclear localization and CRM1-independent nuclear export
    • basic FUNCTION
  • transactivating the promoters responsive to STAT3
  • activating the acute phase response element (APRE) synergistically with STAT3
  • enhancing the nuclear localization of STAT3
  • augmenting STAT3 activity by keeping it in the nucleus
  • novel co-factor that promotes adipocyte differentiation and suppresses osteoblast differentiation
  • potential co-factor in transcriptional regulation that directs bipotential stromal cells and primary osteoblasts to differentiate along the adipocytic rather than osteoblastic lineage
  • might enhance the ability of osteoblastic cells to support osteoclast formation
  • may play a fundamental role in bone and blood-related disorders
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • STAT3 via the N-terminal region of ZNF467
  • the nuclear import receptor importin-7 is a molecule that associated with ZNF467
  • can interact with other transcription factors to regulate their activity
  • can recruit a HDAC associated co-repressor complex to suppress target gene transcription
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS