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FLASH GENE

Symbol

ZNF461

contributors: npt - updated : 24-03-2004

HGNC name	zinc finger protein 461
HGNC id	21629

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19q13.1      Physical location : 37.128.283 - 37.157.739
Synonym name	gonadotropin inducible transcription repressor 1
Synonym symbol(s)	GIOT-1, MGC33911

DNA

TYPE	functioning gene
STRUCTURE	29.00 kb     6 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed ZNF461 6 - 3192 66 563 - -

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic thymus       highly Digestive intestine small intestine         liver       highly Endocrine adrenal gland           pancreas       highly Nervous brain diencephalon hypothalamus     Reproductive female system ovary         male system testis       Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a double KRAB domain at the N terminus
	eleven C2H2 type zinc finger motifs at the C terminus

HOMOLOGY

interspecies

homolog to rat Giot1

Homologene

FAMILY

kruppel family of c2h2-type zn-finger proteins

CATEGORY

regulatory , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION

playing a significant role at the transcription level in the folliculogenesis

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA	DNA binding

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS