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FLASH GENE
Symbol ZNF451 contributors: npt - updated : 13-01-2010
HGNC name zinc finger protein 451
HGNC id 21091
Location 6p12.1      Physical location : 56.954.827 - 57.035.098
Synonym name coactivator for steroid receptors
Synonym symbol(s) KIAA0576, COASTER, dJ417I1.1, KIAA1702, FLJ23421, FLJ53246, FLJ90693, MGC26701
DNA
TYPE functioning gene
STRUCTURE 80.27 kb     15 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC391930 6 similar to ribosomal protein L31 LOC391931 6 similar to replication protein A3, 14kDa; replication protein A3 (14kD) GCLC 6p12 glutamate-cysteine ligase, catalytic subunit LOC391932 6 similar to bA345L23.2 (novel protein with BTB/POZ (broad complex Tramtrack bric-a-brac/Pox virus and zinc finger) domain) LRRC1 6p12.1 leucine-rich repeat-containing 1 C6orf142 6p12.2-p12.1 chromosome 6 open reading frame 142 TINAG 6p12-p11.2 tubulointerstitial nephritis antigen CLNS1B 6p12 chloride channel, nucleotide-sensitive, 1B LOC391933 6 similar to Transforming protein p21b (K-Ras 2B) (Ki-Ras) (c-K-ras) LOC221344 6p12.1 hypothetical LOC221344 LOC389399 6 LOC389399 C6orf143 6p12.1 chromosome 6 open reading frame 143 HCRTR2 6p11-q11 hypocretin (orexin) receptor 2 LOC389400 6 similar to IVFI9356 HMGCLL1 6p12.1 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1 LOC391934 6 similar to nitrogen fixation cluster-like BMP5 6p11.1 bone morphogenetic protein 5 COL21A1 6p12.3-p11.2 collagen, type XXI, alpha 1 LOC221341 6p12.1 similar to RCC1-like BPAG1 6p12-p11 bullous pemphigoid antigen 1, 230/240kDa C6orf65 6p12.1 chromosome 6 open reading frame 65 MRPL30P1 6p12.1 chromosome 6 open reading frame 65 KIAA1586 6p12.1 KIAA1586 ZNF451 6p12.1 zinc finger protein 451 BAG2 6p12.3-p11.2 BCL2-associated athanogene 2 RAB23 6p11.2-p12.3 RAB23, member RAS oncogene family PRIM2A 6p12-p11.1 primase, polypeptide 2A, 58kDa LOC391935 6 similar to glyceraldehyde 3-phosphate dehydrogenase LOC346245 6p12.1 similar to Chromatin assembly factor 1 subunit C (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-Ip48) (Retinoblastoma binding protein p48) (Retinoblastoma-binding protein 4) (RBBP-4) (MSI1 pr LOC389401 6 similar to SMA3 protein LOC391936 6 similar to glyceraldehyde 3-phosphate dehydrogenase LOC389402 6 similar to Chromatin assembly factor 1 subunit C (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-Ip48) (Retinoblastoma binding protein p48) (Retinoblastoma-binding protein 4) (RBBP-4) (MSI1 pr
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 5241 - 1061 - Karvonen (2008)
14 - 5097 - 1013 - Karvonen (2008)
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Reproductivefemale systemuteruscervix  
 male systemtestis   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text stem cells
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • eleven C2H2-type zinc fingers
  • HOMOLOGY
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • zfx/zfy subfamily
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • probable transcriptional activator
  • play a role via SUMO modification and trafficking of transcription regulators between promyelocytic leukemia bodies and nucleoplasm (Karvonen 2008)
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • ion Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS