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FLASH GENE
Symbol ZNF446 contributors: npt - updated : 22-07-2010
HGNC name zinc finger protein 446
HGNC id 21036
Location 19q13.43      Physical location : 58.987.794 - 58.992.596
Synonym name zinc finger protein with KRAB and SCAN domains 20
Synonym symbol(s) FLJ20626, ZKSCAN20, ZSCAN30
DNA
TYPE functioning gene
STRUCTURE 4.80 kb     7 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 1995 - 450 - Liu (2005)
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinerectum highly
Lymphoid/Immunethymus   highly
Nervousnerve   highly
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a KRAB domain
  • three C(2)H(2) zinc fingers domains
  • a scan box domain
  • HOMOLOGY
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may be involved in transcriptional regulation
  • may act as a transcriptional repressor in mitogen-activated protein kinase (MAPK) signaling pathway to mediate cellular functions (Liu 2005)
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS