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FLASH GENE
Symbol ZNF444 contributors: mct/npt - updated : 10-03-2010
HGNC name zinc finger protein 444
HGNC id 16052
Location 19q13.43      Physical location : 56.652.555 - 56.672.261
Synonym name
  • endothelial zinc finger protein 2
  • zinc finger and SCAN domain-containing protein 17
  • Synonym symbol(s) FLJ11137, EZF2, ZSCAN17
    DNA
    TYPE functioning gene
    STRUCTURE 19.71 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    FLJ23469 19q13.42 hypothetical protein FLJ23469 LOC89887 19q13.43 hypothetical protein LOC89887 KLP1 19q13.43 K562 cell-derived leucine-zipper-like protein 1 LOC390975 19 similar to protein kinase Bsk146 FLJ35453 19q13.43 hypothetical protein FLJ35453 FLJ14768 19q13.43 hypothetical protein FLJ14768 MGC23143 LOC388565 19 similar to zinc finger protein 111 LOC147808 19q13.43 similar to zinc finger protein; zinc finger protein Zec; cDNA sequence AF435832 LOC51157 19q13.43 LDL induced EC protein HSPC189 19q13.43 HSPC189 protein HSU79303 19q13.43 protein predicted by clone 23882 U2AF2 19q13.43 U2 (RNU2) small nuclear RNA auxiliary factor 2 EPN1 19q13.43 epsin 1 LOC199680 19q13.43 hypothetical LOC199680 NALP9 19q13.43 NACHT, leucine rich repeat and PYD containing 9 LOC342931 19q13.43 similar to ret finger protein-like 1 LOC390976 19 similar to ret finger protein-like 1 NALP11 19q13.43 NACHT, leucine rich repeat and PYD containing 11 NALP4 19q13.43 NACHT, leucine rich repeat and PYD containing 4 NALP13 19q13.43 NACHT, leucine rich repeat and PYD containing 13 NALP8 19q13.43 NACHT, leucine rich repeat and PYD containing 8 NALP5 19q13.43 NACHT, leucine rich repeat and PYD containing 5 LOC126208 19q13.43 hypothetical protein LOC126208 ZNF444 19q13.43 zinc finger protein 444 GALP 19q13.43 galanin-like peptide precursor LOC342933 19q13.43 similar to zinc finger protein 495 LOC342934 19q13.43 similar to zinc finger protein 495 ZNF495 19q13.43 zinc finger protein 495 LOC390977 19 similar to zinc finger protein 495 LOC284303 19q13.43 hypothetical LOC284303 DKFZp686B2197 FLJ30927 19q13.43 hypothetical protein FLJ30927 FLJ31030 19q13.43 hypothetical protein FLJ31030 FLJ14011 19q13.43 hypothetical zinc finger protein FLJ14011 ZNF471 19q13.43 zinc finger protein 471 ZFP28 19q13.43 zinc finger protein 28 homolog (mouse) LOC388566 19 similar to Zinc finger protein 471 (EZFIT-related protein 1) ZNF71 22q11.2 zinc finger protein 71 (Cos26) LOC147670 19q13.43 hypothetical protein LOC147670 LOC90485 19q13.43 similar to BC37295_3
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2059 - 327 - Adachi (2002)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen    
    Reproductivefemale systemuterus   
     female systemplacenta   
    Respiratorylung    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four C2H2-type zinc fingers
  • a SCAN box domain
  • HOMOLOGY
    interspecies homolog to rattus LOC292569
    Homologene
    FAMILY
  • Krueppel C2H2-type zinc finger protein family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • regulates the gene encoding the scavenger receptor expressed by endothelial cells, by binding to the 5'flanking critical region of the SCARF1 promoter
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • ion Zn2+
  • protein binds to the 5prime-flanking critical region of the SCARF1 promoter activity and increases its promoter activity (Adachi 2002)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    t(19;22)(q13;q12) leading to the novel fusion gene EWSR1-ZNF444 in soft tissue myoepithelial carcinoma (Brandal 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS