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FLASH GENE
Symbol ZNF444 contributors: mct/npt - updated : 10-03-2010
HGNC name zinc finger protein 444
HGNC id 16052
Location 19q13.43      Physical location : 56.652.555 - 56.672.261
Synonym name
  • endothelial zinc finger protein 2
  • zinc finger and SCAN domain-containing protein 17
  • Synonym symbol(s) FLJ11137, EZF2, ZSCAN17
    DNA
    TYPE functioning gene
    STRUCTURE 19.71 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2059 - 327 - Adachi (2002)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen    
    Reproductivefemale systemuterus   
     female systemplacenta   
    Respiratorylung    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four C2H2-type zinc fingers
  • a SCAN box domain
  • HOMOLOGY
    interspecies homolog to rattus LOC292569
    Homologene
    FAMILY
  • Krueppel C2H2-type zinc finger protein family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • regulates the gene encoding the scavenger receptor expressed by endothelial cells, by binding to the 5'flanking critical region of the SCARF1 promoter
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • ion Zn2+
  • protein binds to the 5prime-flanking critical region of the SCARF1 promoter activity and increases its promoter activity (Adachi 2002)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    t(19;22)(q13;q12) leading to the novel fusion gene EWSR1-ZNF444 in soft tissue myoepithelial carcinoma (Brandal 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS