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FLASH GENE

Symbol

ZNF436

contributors: mct - updated : 26/11/2008

HGNC name	zinc finger protein 436
HGNC id	20814

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1p36      Physical location : 23.685.941 - 23.696.357
Synonym symbol(s)	KIAA1710, Zfp46

DNA

TYPE	functioning gene
STRUCTURE	10.42 kb     3 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 4 - 4493 - 470 - Gregory (2006) variant 2 3 - 4315 - 470 - Gregory (2006)

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Reproductive male system prostate

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose     highly

cell lineage

cell lines

fluid/secretion

at STAGE

Text	brain, heart

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	twelve C2H2-type zinc fingers
	one KRAB domain

HOMOLOGY

interspecies	homolog to rattus LOC298558
	homolog to murine Zfp46

Homologene

FAMILY

Krueppel C2H2-type zinc finger protein family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	may be involved in transcriptional regulation
	may act as a negative regulator in gene transcription mediated by the MAPK signaling pathways

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	ion Zn2+

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS