Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ZNF431 contributors: mct - updated : 01-12-2009
HGNC name zinc finger protein 431
HGNC id 20809
Location 19p12      Physical location : 21.324.839 - 21.368.805
Synonym symbol(s) KIAA1969, DKFZp313E0830
DNA
TYPE functioning gene
STRUCTURE 43.92 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
ZNF14 19p13.3-p13.2 zinc finger protein 14 (KOX 6) LOC390898 19 similar to sorting nexin associated golgi protein 1 MGC39821 19p13.11 hypothetical protein MGC39821 ZNF506 19p13.11 zinc finger protein 506 LOC390899 19 similar to hypothetical protein FLJ12488 ZNF253 19p13.1 zinc finger protein 253 ZNF505 19p13.11 zinc finger protein 505 LOC91120 19p13.11 hypothetical ZNF-like protein ZNF90 19p13.1-p12 zinc finger protein 90 (HTF9) LOC388519 19 similar to 40S ribosomal protein S16 ZNF486 19p13.11 zinc finger protein 486 LOC284441 19p13.11 similar to actin-related protein 2 LOC390900 19 similar to hypothetical protein FLJ12488 LOC388520 19 hypothetical gene supported by AK126842 LOC163233 19p13.11 similar to Zinc finger protein 93 (Zinc finger protein HTF34) LOC390901 19 similar to Zinc finger protein 431 LOC199777 19p13.11 similar to DNA-binding protein; zinc finger protein 253 LOC390902 19 similar to Zinc finger protein 93 (Zinc finger protein HTF34) LOC390903 19 similar to Zinc finger protein 93 (Zinc finger protein HTF34) LOC342991 19p13.11 similar to hypothetical protein FLJ12488 ZNF85 19p12 zinc finger protein 85 (HPF4, HTF1) LOC390904 19 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) ZNF430 19p12 zinc finger protein 430 ZNF431 19p12 zinc finger protein 431 LOC148203 19p13.11 hypothetical protein LOC148203 LOC388521 19 similar to hypothetical protein LOC390905 19 similar to hypothetical protein LOC163227 LOC115648 19p13.11 similar to hypothetical protein FLJ13659 ZNF493 19p13.11 zinc finger protein 493 LOC388522 19 similar to Zinc finger protein 429 LOC163227 ZNF43 19p13.1-p12 zinc finger protein 43 (HTF6) ZNF208 19p12 zinc finger protein 208 ZNF257 19q13 zinc finger protein 257 LOC253272 19p13.11 ring finger protein 134 pseudogene LOC163223 19p13.11 similar to Zinc finger protein 208 LOC342994 19p13.11 similar to ribosomal protein L34; 60S ribosomal protein L34 LOC148198 19p13.11 similar to Zinc finger protein 492 LOC342999 19p13.11 similar to ZNF43 protein
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 3861 - 576 - 2011 2117753
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Reproductivemale systemtestis   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 13 C2H2-type zinc fingers
  • one KRAB domain
  • HOMOLOGY
    Homologene
    FAMILY
  • krueppel C2H2-type zinc finger protein family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text
  • nuclear localization of ZNF431 protein is consistent with its role as a transcription factor
  • basic FUNCTION
  • may be involved in transcriptional regulation
  • nuclear transcriptional repressor whose repressive activity depends on its association with HDAC1 and -2
  • directly represses Patched1 (PTCH1) expression and likely functions to repress the hedgehog response in cells
  • role in controlling both PTCH1 basal expression and cellular response to Hh signaling
  • can function as a transcriptional repressor, and its repressive activity is dependent on the KRAB A domain
  • normal function of ZNF431 may be to control Hh responsiveness within physiological range for signal transduction
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • ion Zn2+
  • protein
  • PTCH1 is a direct transcriptional target of ZNF431
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS