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FLASH GENE
Symbol ZNF407 contributors: mct - updated : 22-06-2016
HGNC name zinc finger protein 407
HGNC id 19904
Corresponding disease
MRFDC mental retardation, facial dysmorphism, camptodactyly
Location 18q22.3      Physical location : 72.342.918 - 72.777.628
Synonym symbol(s) FLJ20307, FLJ13839, KIAA1703
DNA
TYPE functioning gene
STRUCTURE 467.94 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
MGC20785 18q22.2 hypothetical protein MGC20785 CD226 18q22.3 CD226 antigen RTTN 18q22.1 rotatin SOCS4 18q22.2 suppressor of cytokine signaling 4 LOC339306 18q22.2 hypothetical LOC339306 LOC342808 18q22.2 similar to 40S ribosomal protein S2 CBLN2 18q23 cerebellin 2 precursor NETO1 18q22.2 neuropilin (NRP) and tolloid (TLL)-like 1 LOC388481 18 LOC388481 FBXO15 18q22.3 F-box only protein 15 HSPC154 18q22.3 HSPC154 protein CYB5 18q23 cytochrome b-5 FAUP1 18 FBR-MuSV-associated ubiquitously expressed (fox derived) pseudogene 1 LOC125704 18q22.3 similar to hypothetical protein B230399E16 CN2 18q22.3 cytosolic nonspecific dipeptidase (EC 3.4.13.18) CN1 18q22.3 carnosinase 1 ZNF407 18q23 zinc finger protein 407 MGC45594 18q22.3 hypothetical protein MGC45594 SDCCAG33 18q22.3 serologically defined colon cancer antigen 33 LOC388482 18 LOC388482 LOC284275 18q23 hypothetical LOC284275 KIAA0222 18q23 hypothetical LOC284275 ZNF236 18q22-q23 zinc finger protein 236 MBP 18q23 myelin basic protein LOC388483 18 LOC388483 GALR1 18q23 galanin receptor 1 LOC390864 18 similar to amino acid feature: Rod protein domain, aa 266 .. 468; amino acid feature: globular protein domain, aa 32 .. 265 LOC125595 18q23 hypothetical LOC125595 LOC390865 18 similar to hypothetical protein LOC390866 18 LOC390866 LOC390867 18 similar to Splicing factor 3A subunit 2 (Spliceosome associated protein 62) (SAP 62) (SF3a66) LOC390868 18 similar to hypothetical protein LOC388484 18 LOC388484 SALL3 18q23 sal-like 3 (Drosophila) ATP9B 18q23 ATPase, Class II, type 9B NFATC1 18q23 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 LOC388485 18 LOC388485 LOC390869 18 similar to immediate early protein homolog LOC147294 18q23 similar to immediate early protein homolog FLJ25715 18q23 hypothetical protein FLJ25715 CTDP1 18q23 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 8008 - 2248 - 2013 23195952
7 - 5851 - 1815 - 2013 23195952
4 - 5625 - 1660 - 2013 23195952
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • zinc finger motifs
  • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • zinc finger protein family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in transcriptional regulation
  • is a transcription factor with an essential role in brain development
  • regulates insulin-stimulated glucose uptake in adipocytes
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • may represent a new modulator of the PPARG signaling pathway
  • regulates insulin-stimulated glucose uptake and glucose transporter 4 (SLC2A4) mRNA
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MRFDC
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS