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FLASH GENE
Symbol ZNF407 contributors: mct - updated : 22-06-2016
HGNC name zinc finger protein 407
HGNC id 19904
Corresponding disease
MRFDC mental retardation, facial dysmorphism, camptodactyly
Location 18q22.3      Physical location : 72.342.918 - 72.777.628
Synonym symbol(s) FLJ20307, FLJ13839, KIAA1703
DNA
TYPE functioning gene
STRUCTURE 467.94 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 8008 - 2248 - 2013 23195952
7 - 5851 - 1815 - 2013 23195952
4 - 5625 - 1660 - 2013 23195952
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • zinc finger motifs
  • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • zinc finger protein family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in transcriptional regulation
  • is a transcription factor with an essential role in brain development
  • regulates insulin-stimulated glucose uptake in adipocytes
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • may represent a new modulator of the PPARG signaling pathway
  • regulates insulin-stimulated glucose uptake and glucose transporter 4 (SLC2A4) mRNA
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MRFDC
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS