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FLASH GENE
Symbol ZNF398 contributors: npt - updated : 16-04-2009
HGNC name zinc finger protein 398
HGNC id 18373
Location 7q36.1      Physical location : 148.823.507 - 148.880.116
Synonym name
  • zinc finger DNA-binding protein p52/p71
  • zinc finger DNA binding protein ZER6
  • zinc finger-estrogen receptor interaction, clone 6
  • Synonym symbol(s) P51, P71, ZER6, KIAA1339
    DNA
    TYPE functioning gene
    STRUCTURE 35.30 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC392145 7 similar to Mtr3 (mRNA transport regulator 3)-homolog; Mtr3 (mRNA transport regulator 3)-homolog (yeast) LOC392146 7 similar to 60S ribosomal protein L32 C7orf33 7q36.1 chromosome 7 open reading frame 33 LOC392147 7 similar to Huntingtin interacting protein K CUL1 7q35-q36 cullin 1 EZH2 7q35 enhancer of zeste homolog 2 (Drosophila) RNY5 7q36 RNA, Y5 small cytoplasmic (associated with Ro protein) ERP70 7q35 protein disulfide isomerase related protein (calcium-binding protein, intestinal-related) DKFZp762I137 7q36.1 hypothetical protein DKFZp762I137 LOC155054 7q36.1 hypothetical protein LOC155054 ZNF398 7q36.1 zinc finger protein 398 ZNF282 7q35-q36 zinc finger protein 282 ZNF212 7q36.1 zinc finger protein 212 LOC389594 7 similar to KIAA1285 protein NPM1P12 7q35 nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 12 KIAA1285 7q36.1 nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 12 FLJ31413 7q36.1 hypothetical protein FLJ31413 LOC392148 7 similar to KIAA1285 protein FLJ12700 7q36.1 hypothetical protein FLJ12700 KIAA1862 7q36 KIAA1862 protein EZI 7q36.1 likely ortholog of mouse zinc finger protein EZI FLJ36112 7q36.1 hypothetical protein FLJ36112 C7orf32 7q36.1 chromosome 7 open reading frame 32 LOC389595 7 hypothetical gene supported by AK127966 MGC3036 7q31-q35 hypothetical protein MGC3036 C7orf29 7q35 chromosome 7 open reading frame 29 RARRES2 7q35 retinoic acid receptor responder (tazarotene induced) 2 LOC389596 7 LOC389596 REPIN1 7q36.1 replication initiator 1 MGC33584 7q36.1 hypothetical protein MGC33584 LOC389597 7 LOC389597 LOC389598 7 similar to expressed sequence AI854703
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 5445 71 642 mammary gland Conroy
    a N terminal HUB-1 domain inhibiting interaction with ER alpha
    - - 5508 52 471 mammary gland Conroy
    internal insertion leading to a shorter protein
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systembreast   
    Urinarykidney   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandular  
    cells
    SystemCellPubmedSpeciesStageRna symbol
     epithelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a KRAB domain
  • a Krüppel-associated box at the N terminus
  • six tandemly arranged zinc finger motifs of the C2H2 Krüppel type at the C terminus
  • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • transcription regulation in hormone responsive cells, controlled by the relative level of expression of two distinct isoforms
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • estrogen receptor alpha (ESR1)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS