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FLASH GENE

Symbol

ZNF397

contributors: mct - updated : 15-02-2011

HGNC name	zinc finger protein 397
HGNC id	18818

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	18q12.1      Physical location : 32.820.993 - 32.838.396
Synonym name	zinc finger and SCAN domain-containing protein 15
	zinc finger protein 47
Synonym symbol(s)	ZNF47, MGC13250, ZSCAN15

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
text	clustered with ZNF396
STRUCTURE	17.40 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001135178 4 - 2644 NP_001128650 - 534 widely 2003 12801647 also called ZNF397-fu nuclear NM_032347 6 - 1494 NP_115723 - 275 widely 2003 12801647 also called ZNF397-nf nuclear and cytoplasmic

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas       moderately Reproductive male system testis     highly   male system prostate     moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a SCAN domain in the N-terminal region, necessary but not sufficient for centromere localisation
	nine consecutive C(2)H(2) zinc finger repeats in the C-terminal region

conjugated

MetalloP

HOMOLOGY

Homologene

FAMILY

krueppel C2H2-type zinc-finger protein family

CATEGORY

regulatory , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus
text	co-localisation of ZNF397 with the constitutive centromere protein CENPA during interphase and early prophase

basic FUNCTION	may be involved in transcriptional regulation
	interphase to early prophase-specific and SCAN domain-containing mammalian centromere protein with a possible role in transcription at the centromere

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	Zn2+

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS