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FLASH GENE
Symbol ZNF394 contributors: - updated : 22-03-2006
HGNC name zinc finger protein 394
HGNC id 18832
Location 7q11.21      Physical location : 99.090.854 - 99.097.877
Synonym name zinc finger protein 99
Synonym symbol(s) FLJ12298, ZNF99
DNA
TYPE functioning gene
STRUCTURE 7.00 kb     3 Exon(s)
MAPPING cloned Y linked N status provisional
Physical map
SMURF1 7q21.1-q31.1 zinc finger protein 36 (KOX 18) LOC389539 7 similar to importin alpha 1b ARPC1A 7q22.1-q31.33 actin related protein 2/3 complex, subunit 1A, 41kDa ARPC1B 7q22.1-q31.33 actin related protein 2/3 complex, subunit 1B, 41kDa PDAP1 7q11.21 PDGFA associated protein 1 G10 7q11.21 PDGFA associated protein 1 CPSF4 7q22.1 cleavage and polyadenylation specific factor 4, 30kDa KIAA0632 7q22.1 cleavage and polyadenylation specific factor 4, 30kDa ATP5J2 7q21.3-q22 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit f, isoform 2 LOC285989 7q22.1 hypothetical protein LOC285989 ZNF394 7q22.1 zinc finger protein 394 ZFP95 7q22 zinc finger protein 95 homolog (mouse) DKFZp727G131 7q22.1 hypothetical protein DKFZp727G131 VIK 7q22.1 vav-1 interacting Kruppel-like protein ZNF498 7q22.1 zinc finger protein 498 CYP3A5 7q21.3-q22.1 cytochrome P450, family 3, subfamily A, polypeptide 5 CYP3A5P1 7q21.3-q22.1 cytochrome P450, family 3, subfamily A, polypeptide 5 pseudogene 1 CYP3A7 7q21.3-q22.1 cytochrome P450, family 3, subfamily A, polypeptide 7 CYP3A5P2 7q21.3-q22.1 cytochrome P450, family 3, subfamily A, polypeptide 5 pseudogene 2 CYP3A4 7q21.3-q22.1 cytochrome P450, family 3, subfamily A, polypeptide 4 CYP3A43 7q21.1 cytochrome P450, family 3, subfamily A, polypeptide 43 TRIM4 7q22-q31.1 tripartite motif-containing 4 AZGP1 7q22.1 alpha-2-glycoprotein 1, zinc LOC392078 7 hypothetical gene supported by BC022382 ZNF36 7q21.3-q22.1 zinc finger protein 36 (KOX 18) ZNF38 7q21-q22 zinc finger protein 38 ZNF3 7q22.1 zinc finger protein 3 (A8-51) COPS6 7q22.1 zinc finger protein 3 (A8-51)
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Lymphoid/Immunespleen   highly
 tonsils   highly
Nervousbrain   highly
Respiratoryrespiratory tracttrachea  highly
Skin/Tegumentskin    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion blood, lymph
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal leucine-rich region (LER or SCAN domain),
  • a well-conserved kruppel-associated box domain
  • C-terminus 7 C2H2 zinc finger motifs in tandem arrays with the highly conserved space region of the H/C-link
  • one KRAB domain
  • one SCAN box domain
  • HOMOLOGY
    Homologene
    FAMILY krüppel C2H2-type zinc-finger protein family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in regulation of transcription, DNA-dependent
  • upon overexpression, inhibits the transcriptional activities of c-jun and AP1 reporters
  • new transcriptional repressor in mitogen-activated protein kinase signaling pathways and may play an important role in cardiac development and/or cardiac function
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, other,
  • ion Zn2+
  • Acyl-CoA binding
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS