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FLASH GENE
Symbol ZNF385A contributors: mct - updated : 25-05-2016
HGNC name zinc finger protein 385A
HGNC id 17521
Location 12q13.13      Physical location : 54.762.919 - 54.785.083
Synonym name
  • zinc finger protein 385
  • hematopoietic zinc finger protein
  • retinal zinc finger protein
  • Synonym symbol(s) HZF, RZF, ZFP385, ZNF385, DKFZp586G1122
    DNA
    TYPE functioning gene
    STRUCTURE 22.18 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 2349 - 386 - 2004 15527981
    7 - 2106 - 305 - 2004 15527981
    9 - 2494 38 366 - 2004 15527981
    9 - 2539 - 366 - 2004 15527981
    6 - 2201 - 285 - 2004 15527981
    7 - 2444 - 366 - 2004 15527981
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Nervousbrainlimbic systemhippocampus   Homo sapiens
    Reproductivefemale systemuteruscervix highly
    Visualeyeretina  predominantly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmegakaryocyte
    Nervousneuron Homo sapiens
    NervousPurkinje cell Homo sapiens
    Nervouspyramidal cell Homo sapiens
    Visualcone photoreceptor Homo sapiens
    Visualrod photoreceptor Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three C2H2-type zinc fingers, three widely spaced C(2)H(2)-type zinc finger motifs
  • three potential nuclear localisation signals
  • clusters of charged amino acids in the protein
  • HOMOLOGY
    interspecies homolog to rattus Zfp385a (96.5 pc)
    homolog to murine Zfp385a (96.2 pc)
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • required for megakaryocytes development and hemostasis
  • may be involved in transcriptional regulation
  • shuttling regulatory protein expressed in photoreceptors of retina that may be involved in mRNA or protein regulation of photoreceptor-specific genes and therefore have role in retinal disease mechanisms
  • playing a critical role in the adipogenesis regulatory cascade
  • may not be a nucleic acid binding protein, unlike most other zinc-finger proteins
  • is a shuttling regulatory protein expressed in photoreceptors of the human retina that may be involved in mRNA or protein regulation of photoreceptor-specific genes and therefore have role in retinal disease mechanisms
  • may likely functions as a key player in regulating cell fate decisions in response to genotoxic stress
  • plays important roles in mRNA translation in cerebellar Purkinje cells and adipocytes
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • ion Zn2+
  • protein
  • ZNF385A regulates TP53 expression in cooperation with ELAVL1
  • CDKN2A increases the concentration of TP53 through posttranscriptional control of TP53 mRNA, suggesting critical roles for the RNA-binding proteins ZNF385A and ELAVL1 in TP53 induction
  • DISC1 binds ITPR1 mRNA with ZNF385A, thereby regulating its dendritic transport for synaptic plasticity
  • cell & other
    REGULATION
    Other is transcriptionally regulated by the TP53 tumor suppressor protein
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • exposure of Hzf null mice to ionizing radiation resulted in enhanced apoptosis in several organs, as compared to in wild-type mice
  • mice lacking Hzf (Hzf(-/-) mice) exhibited severe impairments of motor coordination and cerebellum-dependent motor learning