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FLASH GENE
Symbol ZNF382 contributors: npt/mct - updated : 23-12-2009
HGNC name zinc finger protein 382
HGNC id 17409
Location 19q13.12      Physical location : 37.096.220 - 37.119.498
Synonym name
  • multiple-zinc-finger-Kruppel-associated box protein KS1
  • KRAB/zinc finger suppressor protein 1
    • Synonym symbol(s) KS1, FLJ14686
    DNA
    TYPE functioning gene
    STRUCTURE 19.85 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 3983 - 550 - -
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text widely in fetal tissues
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal well-conserved Krupple-associated box domain that consists of KRAB boxes A and B
  • C-terminal Krupple-type zinc-finger domain possessing 13 C(2)H(2) zinc-finger motifs in tandem arrays
    • HOMOLOGY
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may be playing a role in renal development and involved in the repair of the kidney after ischemia-reperfusion or folic acid administration
  • playing a potential role in heart development and function
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    aberrantly methylated promoter associated CpG islands in acute lymphocytic leukemia (Kuang 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS