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FLASH GENE
Symbol ZNF366 contributors: mlc - updated : 07-11-2007
HGNC name zinc finger protein 366
HGNC id 18316
Location 5q13.2      Physical location : 71.739.233 - 71.803.249
Synonym name
  • Dendritic cell-specific transcript
  • Synonym symbol(s) FLJ39796, DC-SCRIPT
    DNA
    TYPE functioning gene
    STRUCTURE 64.00 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2770 - 744 - Triantis (2006)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
    Lymphoid/Immunethymus   highly
    Reproductivefemale systemplacenta  highly
    Respiratoryrespiratory tracttrachea  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • eleven zinc finger motifs of the C2H2 type
  • a proline-rich region
  • an acidic region
  • conjugated MetalloP
    HOMOLOGY
    interspecies homolog to murine DC- script (80 p 100)
    Homologene
    FAMILY zinc finger protein family
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • ESR1-interacting protein, which is a potent corepressor of ESR1 activity
  • may play an important role in regulating the expression of genes in response to estrogen
  • dendritic cell marker that could be involved in transcriptional repression
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    Zn2+
    protein
  • PLAG1
  • interacting with ESR1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS