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FLASH GENE
Symbol ZNF366 contributors: mlc - updated : 07-11-2007
HGNC name zinc finger protein 366
HGNC id 18316
Location 5q13.2      Physical location : 71.739.233 - 71.803.249
Synonym name
  • Dendritic cell-specific transcript
    • Synonym symbol(s) FLJ39796, DC-SCRIPT
    DNA
    TYPE functioning gene
    STRUCTURE 64.00 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC391791 5 similar to cadherin 12, type 2 preproprotein; Br-cadherin; cadherin-12; N-cadherin 2; brain-cadherin; neuronal cadherin 2; cadherin, neural type, 2 SMA3 5q13 SMA3 LOC389294 5 similar to bA110H4.2 (similar to membrane protein) LOC391792 5 similar to SMA3 protein LOC340089 5q13.2 similar to bA110H4.2 (similar to membrane protein) LOC391793 5 similar to cadherin 12, type 2 preproprotein; Br-cadherin; cadherin-12; N-cadherin 2; brain-cadherin; neuronal cadherin 2; cadherin, neural type, 2 SERF1A 5q13.1 small EDRK-rich factor 1A (telomeric) SMN2 5q13.1 survival of motor neuron 2, centromeric LOC389295 5 LOC389295 LOC389296 5 similar to Beta-glucuronidase precursor (Beta-G1) LOC389297 5 similar to bA110H4.2 (similar to membrane protein) LOC389298 5 similar to bA110H4.2 (similar to membrane protein) LOC389299 5 similar to Beta-glucuronidase precursor (Beta-G1) LOC391794 5 similar to cadherin 12, type 2 preproprotein; Br-cadherin; cadherin-12; N-cadherin 2; brain-cadherin; neuronal cadherin 2; cadherin, neural type, 2 PMCHL2 5q13 pro-melanin-concentrating hormone-like 2 BDP1 5q13 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB MCCC2 5q12-q13 methylcrotonoyl-Coenzyme A carboxylase 2 (beta) CART 5q13.1 Homo sapiens cocaine- and amphetamine-regulated transcript (CART), mRNA. MAP1B 5q13 microtubule-associated protein 1B MRPS27 5q13.2 mitochondrial ribosomal protein S27 FLJ12598 5q13.2 hypothetical protein FLJ12598 LOC391795 5 similar to ribosomal protein L10a ZNF366 5q13.1 zinc finger protein 366 LOC389300 5 LOC389300 KPNB2 5p14.2-q22.3 karyopherin (importin) beta 2 LOC115548 5q13.2 hypothetical protein BC014311 LOC134285 5q13.3 hypothetical protein LOC134285 MGC13034 5q13.3 hypothetical protein MGC13034 LOC389301 5 similar to nonhistone chromosomal protein HMG-17 - rat LOC389302 5 LOC389302 FOXD1 5q12-q13 forkhead box D1 BTF3 5p13.2 basic transcription factor 3 LOC220793 5q13.3 similar to hepatitis C virus core-binding protein 6; cervical cancer oncogene 3 ANKRA2 5q12-q13 ankyrin repeat, family A (RFXANK-like), 2 FLJ12787 5q13.3 hypothetical protein FLJ12787 PRO1942 5q13.3 hypothetical protein PRO1942 RGNEF 5q13.3 Rho-guanine nucleotide exchange factor ENC1 5q12-q13.3 ectodermal-neural cortex (with BTB-like domain) HEXB 5q12 hexosaminidase B (beta polypeptide) EFG2 5q13 hexosaminidase B (beta polypeptide) TINP1 5q13.3 TGF beta-inducible nuclear protein 1 KIAA0888 5q13.3 KIAA0888 protein LOC260421 5q13 actin related protein 2/3 complex subunit 1A pseudogene LOC389303 5 hypothetical gene supported by BC039003 LOC391796 5 similar to hypothetical protein FLJ10891 C2GNT3 5q12 similar to hypothetical protein FLJ10891
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2770 - 744 - Triantis (2006)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
    Lymphoid/Immunethymus   highly
    Reproductivefemale systemplacenta  highly
    Respiratoryrespiratory tracttrachea  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • eleven zinc finger motifs of the C2H2 type
  • a proline-rich region
  • an acidic region
    • conjugated MetalloP
    HOMOLOGY
    interspecies homolog to murine DC- script (80 p 100)
    Homologene
    FAMILY zinc finger protein family
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • ESR1-interacting protein, which is a potent corepressor of ESR1 activity
  • may play an important role in regulating the expression of genes in response to estrogen
  • dendritic cell marker that could be involved in transcriptional repression
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    Zn2+
    protein
  • PLAG1
  • interacting with ESR1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS