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FLASH GENE
Symbol ZNF365 contributors: mct/npt - updated : 21-08-2015
HGNC name zinc finger protein 365
HGNC id 18194
Location 10q21.2      Physical location : 64.133.915 - 64.431.771
Synonym name
  • KIAA0844 protein
  • talanin
  • Synonym symbol(s) KIAA0844, MGC41821, MGC87345, Su48, UAN, ZNF365D,TALN
    DNA
    TYPE functioning gene
    STRUCTURE 297.85 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    IPMK MDS029 UBE2D1 10q11.2-q21 ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) TFAM 10q21 transcription factor A, mitochondrial BICC1 10q21.3 bicaudal C homolog 1 (Drosophila) LOC389971 10 hypothetical gene supported by U78798; NM_004620 KIAA1796 10q11 KIAA1796 protein FAM13C1 10q21 family with sequence similarity 13, member C1 MRPL50P4 10q23.1 family with sequence similarity 13, member C1 C10orf36 D10S170 ANK3 10q21 ankyrin 3, node of Ranvier (ankyrin G) LOC387684 10 similar to ADP-ribosylation factor-like protein 4 CDC2 10q21.1 cell division cycle 2, G1 to S and G2 to M RHOBTB1 10q22.1 Rho-related BTB domain containing 1 MGC35010 10q21.3 hypothetical protein MGC35010 MGC44593 10q21.3 hypothetical protein MGC44593 MRF2 10q21.3 hypothetical protein MGC44593 RTKN2 10q21.3 rhotekin 2 ZNF365 10q21.2 zinc finger protein 365 LOC387685 10 LOC387685 ATQL4 10q21 antiquitin-like 4 C10orf22 10q21.3 chromosome 10 open reading frame 22 EGR2 10q21.1 early growth response 2 (Krox-20 homolog, Drosophila) NRBF-2 TRIP8 10q22.1 thyroid hormone receptor interactor 8 LOC389972 10 similar to Px19-like protein MGC14425 10q22.1 hypothetical protein MGC14425 LOC221035 10q22.1 similar to DNA segment, Chr 10, University of California at Los Angeles 1 MRPL35P2 10q21.3 similar to DNA segment, Chr 10, University of California at Los Angeles 1 RPL7AP1 10q21.2 similar to DNA segment, Chr 10, University of California at Los Angeles 1 LOC143173 10q22.1 similar to activator of S phase kinase ANXA2P3 10q21-q22 annexin A2 pseudogene 3 VR22 10q22.2 alpha-catenin-like protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 4223 - 407 - 2006 16547491
  • ZNF365 A
  • 5 - 1726 - 333 - 2006 16547491
  • ZNF365B
  • 8 - 3414 - 462 - 2006 16547491
  • ZNF365C
  • - - 2695 24 216 - 2006 16547491
  • encoding the talanin, ZNF365D
  • emerged during primate evolution from a noncoding genomic sequence that evolved in a standard gene structure
  • associated with susceptibility to uric acid nephrolithiasis
  • EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid    
    Nervousbrain    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal zinc finger domain, C2H2 type
  • a coiled coil-containing subdomain both sufficient and required for its centrosome localization
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    basic FUNCTION
  • centrosomal protein that can form a protein complex with NDE1 in the centrosome and plays an important role for successful mitosis
  • playing an essential role for cell division and abnormalities may cause aberrant chromosome segregation and may contribute to aneuploidy and malignant transformation
  • plays a critical role in stabilizing fragile sites within the genome and telomeres and maintaining genome stability
  • is necessary for timely resolution of replication intermediates of genomic fragile sites and, thus, for suppression of genomic instability
  • homologous recombination (HR) repair-dependent function of ZNF365 in preventing genomic instability
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with NDE1
  • direct TP53 target that promotes genome stability (TP53-ZNF365 axis contributes to genomic stability in the setting of telomere dysfunction)
  • interacts with poly(ADP-ribose) polymerase (PARP1) to tether MRE11 to the DNA end resection site
  • cell & other
    REGULATION
    induced by DNA double-strand break (DSB) signals, is involved in the homologous recombination (HR) repair pathway, and maintains genome integrity during DNA replication
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    results in delayed mitotic progression and exit due to increased replication stress, ultimately leading to cytokinesis failure, re-duplication of centrosomes, and increased aneuploidy
    Susceptibility
  • to uric acid nephrolithiasis
  • to mammographic density and breast cancer
  • to Crohn disease
  • Variant & Polymorphism other
  • mutation in ZNF365D associated to uric acid nephrolithiasis
  • rs10995190 in ZNF365 associated with susceptibility to breast cancer
  • variants in ZNF365 isoform D are associated with Crohn disease
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS