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FLASH GENE
Symbol ZNF346 contributors: mct - updated : 30-06-2012
HGNC name zinc finger protein 346
HGNC id 16403
Location 5q35.2      Physical location : 176.449.696 - 176.493.743
Synonym name
  • Double-stranded RNA-binding zinc finger protein JAZ
  • just another zinc finger protein
  • Synonym symbol(s) JAZ, Zfp346
    DNA
    TYPE functioning gene
    STRUCTURE 44.06 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 3089 - 294 - 2004 15254228
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel   moderately
    Digestivemouthtongue  moderately
    Lymphoid/Immunethymus   predominantly
    Nervousbrain   moderately
    Reproductivefemale systembreastmammary gland moderately
     female systemuterus  moderately
     male systemprostate  moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four homologous C2H2-type zinc finger domains
  • unusually long helix-loop linker sequences beginning with basic residues
  • HOMOLOGY
    interspecies ortholog to murine Zfp346
    Homologene
    FAMILY
    CATEGORY regulatory , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • involved in cell growth and survival
  • functions to mediate G1 cell-cycle arrest followed by apoptosis in a TP53-dependent mechanism that is associated with up-regulation of CDKN1A and BAX, and dephosphorylation of RB
  • novel negative regulator of cell growth by positively regulating TP53
  • unique dsRNA binding zinc finger protein that functions as a direct, positive regulator of TP53 transcriptional activity to mediate G1 cell cycle arrest
  • plays a dual role in cell cycle regulation by both repressing E2F1 transcriptional activity and activating p53 to facilitate efficient growth arrest in response to cellular stress
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism nucleic
    signaling
  • RNA processing
  • a component
    INTERACTION
    DNA
  • RNA/DNA hybrids
  • RNA
  • double-stranded RNA
  • RNA/DNA hybrids
  • small molecule metal binding,
  • Zn2+
  • protein
  • associates with TP53 to stimulate its transcriptional activity in TP53-expressing cells
  • can also negatively regulate the cell cycle in a novel, TP53-independent mechanism resulting from the direct interaction with E2F1, a key intermediate in regulating cell proliferation and tumor suppression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS