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FLASH GENE

Symbol

ZNF331

contributors: mct - updated : 08-10-2014

HGNC name	zinc finger protein 331
HGNC id	15489

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19q13.42      Physical location : 54.024.176 - 54.083.523
Synonym name	rearranged in in thyroid adenomas
	zinc finger protein 463
	reactivation of p53 and induction of tumor cell apoptosis
	C2H2-like zinc finger protein
Synonym symbol(s)	RITA, ZNF361, ZNF463

DNA

TYPE	functioning gene
STRUCTURE	59.35 kb     8 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed ZNF331 A - - 573 - - - 1999 10502321 ZNF331 B - - 641 - - - 1999 10502321 ZNF331C - - 688 - - - 1999 10502321 ZNF331D - - 599 - - - 1999 10502321 ZNF331E - - 598 - - - 1999 10502321 ZNF331F - - 670 - - - 1999 10502321 ZNF331 G - - 740 - - - 1999 10502321 NM_018555 7 - 5163 NP_061025 - 463 - 1999 10502321 NM_001079906 6 - 4151 NP_001073375 - 463 - 1999 10502321 NM_001253798 7 - 4167 NP_001240727 - 463 - 1999 10502321 NM_001253799 6 - 4137 NP_001240728 - 463 - 1999 10502321 NM_001253800 6 - 4096 NP_001240729 - 463 - 1999 10502321 NM_001253801 5 - 3913 NP_001240730 - 463 - 1999 10502321 NM_001079907 6 - 4171 NP_001073376 - 463 - 1999 10502321

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine thyroid         Nervous brain forebrain cerebral lobe frontal   Reproductive female system uterus         male system testis       Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Muscular smooth uterus myometrium

cell lineage
cell lines	follicular thyroid adenoma cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one KRAB domain, Krüppel-associated box at the N terminus
	twelve tandemly arranged C2H2 Krüppel type zinc finger motifs at the C terminus

conjugated

PhosphoP

HOMOLOGY

interspecies	ortholog to chimpanzee znf331
	ortholog to dog znf331

Homologene

FAMILY

zinc finger protein family C2H2 type, KRAB subfamily

CATEGORY

transcription factor , tumor suppressor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	may be playing a role in renal development
	involved in the repair of the kidney after ischemia- reperfusion or folic acid administration
	blocking TP53-MDM2 interactiona, activating TP53 in tumors and inducing massive apoptosis ( candidate for anticancer drugs that targets tumors with wild-type TP53)
	involved in the development of follicular adenomas
	possesses important functions for the suppression of gastric carcinogenesis as a novel functional tumor-suppressor gene

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

development

text	spermatogenesis

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	Zn2+

protein

binding to TP53 and inducing its accumulation in tumor cells

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   translocation     t(5;19) (q13;q13)and t(1;19) (p35-p36.1;q13) in thyroid adenomas tumoral   deletion     in thyroid follicular adenoma tumoral     --low   in 71p100 gastric cancer cell lines, by promoter hypermethylation

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS