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FLASH GENE
Symbol ZNF318 contributors: - updated : 07-02-2007
HGNC name zinc finger protein 318
HGNC id 13578
Location 6pter-p12.1      Physical location : 43.303.808 - 43.337.181
Synonym name
  • zinc finger protein 318 homolog mouse
  • testicular zinc finger
  • Synonym symbol(s) ZFP318, FLJ21852, HRIHFB2436, TZF
    DNA
    TYPE functioning gene
    STRUCTURE 33.00 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    RPL7L1 6p21.1 ribosomal protein L7-like 1 PTCRA 6p21.2-p21.3 pre T-cell antigen receptor alpha TNRC5 6pter-p12.1 trinucleotide repeat containing 5 LOC389390 6 LOC389390 RPL24P4 6p21.1 ribosomal protein L24 pseudogene 4 GNMT 6p12 glycine N-methyltransferase PEX6 6p21.1 peroxisomal biogenesis factor 6 PPP2R5D 6p21.1 protein phosphatase 2, regulatory subunit B (B56), delta isoform MEA 6p21.3-p21.1 male-enhanced antigen KLHDC3 6p21.1 kelch domain containing 3 C6orf153 6p21.1 chromosome 6 open reading frame 153 KIAA0076 6p21.1 chromosome 6 open reading frame 153 MRPL2 6p21.3 mitochondrial ribosomal protein L2 KNSL8 6p21.1 kinesin-like 8 PTK7 6p21.1-p12.2 PTK7 protein tyrosine kinase 7 SRF 6p12.3 serum response factor (c-fos serum response element-binding transcription factor) PARC 6p21.1 p53-associated parkin-like cytoplasmic protein C6orf108 6p21.1 chromosome 6 open reading frame 108 TTBK1 6p21.1 tau tubulin kinase 1 SLC22A7 6p21.2-p21.1 solute carrier family 22 (organic anion transporter), member 7 LOC389391 6 similar to thymus LIM protein TLP-B ZNF318 6pter-p12.1 zinc finger protein 318 ABCC10 6p21.2-p21.1 ATP-binding cassette, sub-family C (CFTR/MRP), member 10 EGFL9 6p21.1 EGF-like-domain, multiple 9 TJP4 6p12.3 tight junction protein 4 (peripheral) C6orf154 6p21.1 chromosome 6 open reading frame 154 C6orf109 6p21.1 chromosome 6 open reading frame 109 POLR1C 6p21.1 polymerase(RNA)1 polypeptide C, 30kDa XPO5 6p21.1 exportin 5 POLH 6p21.1-p12 polymerase (DNA directed), eta GTPBP2 6p21-p12 GTP binding protein 2 MAD2L1BP 6p21.1 MAD2L1 binding protein C6orf206 6p21.1 chromosome 6 open reading frame 205 MRPS18A 6p21.3 mitochondrial ribosomal protein S18A
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Nervousnervecranial nerve  highly
    Reproductivemale systemtestis   
    Visualeyeretina   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelial    
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousoptic nerve
    Reproductivespermatid
    Reproductivespermatocyte
    cell lineage
    cell lines
    fluid/secretion lymph
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a zinc finger domain of the C2H2 type, two matrin-type zinc fingers
  • four basic amino-acid rich domains
  • a myosin II-homology domain
  • conjugated MetalloP
    HOMOLOGY
    interspecies ortholog to murine Zfp318
    Homologene
    FAMILY
    CATEGORY structural protein , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • transcriptional regulator during spermatogenesis in particular, during meiotic division
  • acting as a novel corepressor of AR
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS development
    text spermatogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacts with the N-terminal domain of AR (binding to the activation function-1 (AF-1) domain (N-terminal transactivating domain) of AR protein )
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS