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FLASH GENE
Symbol ZNF287 contributors: npt - updated : 17-04-2009
HGNC name zinc finger protein 287
HGNC id 13502
Location 17p11.2      Physical location : 16.453.630 - 16.472.520
Synonym name zinc finger protein with KRAB and SCAN domains 13
Synonym symbol(s) ZKSCAN13, MGC126536, MGC141923
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 17.76 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
ADORA2B 17p11.2 adenosine A2b receptor FLJ20343 17p11.2 hypothetical protein FLJ20343 NCOR1 17-p11.2 nuclear receptor co-repressor 1 PIGL 17p12-p11.2 phosphatidylinositol glycan, class L p30 17p11.2 nuclear protein p30 UBB 17p12-p11.1 ubiquitin B TRPV2 17p11.2 transient receptor potential cation channel, subfamily V, member 2 MGC40157 17p11.2 hypothetical protein MGC40157 LOC388341 17 similar to Hypothetical protein LOC192976 ZNF287 17p11.2 zinc finger protein 287 LOC284045 17p11.2 hypothetical gene supported by NM_006275; BC006832; U30828; U30829; U30883 KIAA1349 17p11.2 KIAA1349 protein LOC390766 17 similar to Ribonuclease H1 (RNase H1) (Ribonuclease H type II) LOC147226 17p11.2 similar to yeast Upf3, variant A pseudogene LOC252841 17p11.2 signal recognition particle 68kD pseudogene LOC266619 17p11.2 nitric oxide synthase 2A (inducible, hepatocytes) pseudogene LOC353194 17p11.2 keratin pseudogene LOC388342 17 similar to Keratin, type I cytoskeletal 16 (Cytokeratin 16) (K16) (CK 16) LOC388343 17 similar to Keratin, type I cytoskeletal 14 (Cytokeratin 14) (K14) (CK 14) LOC147228 17p11.2 keratin pseudogene LOC339186 17p11.2 keratin pseudogene CLPSMCR 17p11.2 coactosin-like, Smith Magenis syndrome chromosome region LOC390768 17 similar to FLJ00050 protein LOC96597 17p11.2 hypothetical protein LOC96597 TNFRSF13B 17p11.2 tumor necrosis factor receptor superfamily, member 13B M-RIP 17p11.2 myosin phosphatase-Rho interacting protein
regionally located in the Smith-Magenis critical region
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 4278 88.2 761 - Lucas (2001)
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one KRAB (Krüppel-associated box) domain
  • one SCAN box mediating self-association and oligomerization
  • several zinc finger motifs of the C2H2 type at the C terminus
  • conjugated MetalloP
    HOMOLOGY
    interspecies ortholog to murine Zfp287
    ortholog to Drosophila aef1
    ortholog to C.elegans c5587.12
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • potential transcriptional regulator
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    in Smith-Magenis syndrome
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS