Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ZNF281 contributors: mct - updated : 14-11-2017
HGNC name zinc finger protein 281
HGNC id 13075
Location 1q32.1      Physical location : 200.375.425 - 200.379.166
Synonym name
  • GC-box-binding zinc finger protein 1
  • transcription factor ZBP-99
  • zinc finger DNA-binding protein 99
  • Synonym symbol(s) ZNP99, ZBP99, FLJ12859, FLJ14378, GZP1
    DNA
    TYPE functioning gene
    STRUCTURE 78.66 kb     3 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 4904 96.8 895 - 2016 26300006
    3 - 4800 - 859 - 2016 26300006
    2 - 4908 - 895 - 2016 26300006
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymphocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta,highly
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four Krüppel type zinc finger motifs
  • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • regulating ornithine decarboxylase gene expression
  • regulating gastrin gene expression
  • involved in transcriptional regulation
  • mediates NANOG autorepression through recruitment of the NuRD complex and inhibits somatic cell reprogramming
  • epithelial-mesenchymal transition (EMT)-inducing transcription factor (EMT-TF)
  • zinc-finger factor involved in the control of cellular stemness and epithelial-mesenchymal transition (EMT)
  • is a key transcriptional regulator for primed pluripotency that also functions as a barrier toward achieving naive pluripotency in ESCs
  • involved in embryonic stem cell differentiation and tissue development
  • role of ZNF281 in pancreatic cancer progression
  • acts at a nexus of cardiac and inflammatory gene programs, which exert opposing influences on fibroblast to cardiac reprogramming
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to the GC rich promoter element of gastrin and ODC
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • directly activate NANOG expression by binding to a site in the promoter in very close proximity to the POU5F1 and SOX2 binding sites
  • is required for NANOG binding to its own promoter, suggesting that NANOG-associated repressive complex(es) involving ZNF281 may fine-tune NANOG expression for pluripotency of ESCs
  • ZNF281 plays an important role in the maintenance and osteogenic differentiation of stem cells via the transcriptional regulation of genes including CTNNB1
  • NANOG is subjected to a negative autoregulatory mechanism, i.e., autorepression, in ESCs, and such autorepression requires the coordinated action of the NANOG partner and transcriptional repressor ZNF281
  • as ZNF281 physically interacts with the transcription factors NANOG, OCT4, SOX2, and MYC, it has been implicated in the regulation of pluripotency, stemness, and cancer
  • involvement of ZNF281 in the cellular response to genotoxic stress through the control exercised on the expression of genes that act in different repair mechanisms
  • ZFP281 interacts with TET1, but not TET2
  • ZFP281 is a critical factor generally associating with AFF3 at enhancers and functioning together with AFF3 in regulating the expression of a subset of genes
  • promotes pancreatic cancer cells proliferation and invasion by interacting and up-regulating CTNNB1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS