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FLASH GENE
Symbol ZNF274 contributors: mct - updated : 18-01-2014
HGNC name zinc finger protein 274
HGNC id 13068
Location 19q13.43      Physical location : 58.694.395 - 58.724.927
Synonym name
  • KRAB zinc finger protein HFB101
  • zinc finger protein with KRAB and SCAN domains 19
  • zinc finger protein zfp2
  • Synonym symbol(s) ZKSCAN19, DKFZp686K08243, FLJ37843, HFB101, ZF2, ZSCAN51
    DNA
    TYPE functioning gene
    STRUCTURE 30.57 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    ZNF494 19q13.43 zinc finger protein 494 LOC90233 19q13.43 hypothetical protein BC005868 ZNF154 19q13.4 zinc finger protein 154 (pHZ-92) FLJ23506 19q13.43 hypothetical protein FLJ23506 FLJ38288 19q13.43 hypothetical protein FLJ38288 FLJ20070 19q13.43 hypothetical protein FLJ20070 FLJ21603 19q13.43 hypothetical protein FLJ21603 ZF6 19q13.43 zinc finger protein zfp6 LOC387621 19 hypothetical gene supported by NM_017961 LOC390982 19 hypothetical gene supported by U71363 MGC34079 19q13.43 hypothetical protein MGC34079 KIAA1956 19q13.43 KIAA1956 protein ZNF256 19q13.43 zinc finger protein 256 LOC390983 19 similar to 60S ribosomal protein L19 MGC41906 19q13.43 hypothetical protein MGC41906 FLJ14260 19q13.4 hypothetical protein FLJ14260 LOC390984 19 similar to putative pheromone receptor FLJ33779 19q13.43 hypothetical protein FLJ33779 ZNF135 19q13.4 zinc finger protein 135 (clone pHZ-17) FLJ12895 19q13.43 hypothetical protein FLJ12895 LOC390985 19 similar to hypothetical protein FLJ12586 FLJ12586 19q13.43 hypothetical protein FLJ12586 ZNF274 19q13.43 zinc finger protein 274 LOC125910 19q13.43 similar to 40S ribosomal protein S15a LOC388568 19 LOC388568 AF020591 ZNF8 19q13.43 zinc finger protein 8 (clone HF.18) LOC113386 19q13.43 similar to envelope protein LOC390986 19 similar to zinc finger protein 135 (clone pHZ-17); zinc finger protein 61 HKR2 19pter-p13.3 GLI-Kruppel family member HKR2 A1BG 19q11-q13.2 alpha-1-B glycoprotein ZNF497 19q13.43 zinc finger protein 497 RPS5 19q13.4 ribosomal protein S5 FLJ39005 19q13.43 hypothetical protein FLJ39005 LOC201514 19q13.43 hypothetical protein LOC201514 ZNF132 19q13.4 zinc finger protein 132 (clone pHZ-12) LOC388569 19 similar to Zinc finger protein 324 (Zinc finger protein ZF5128) ZNF324 19q13.43 zinc finger protein 324 FLJ20626 19q13.43 hypothetical protein FLJ20626 SLC27A5 19q13.4 solute carrier family 27 (fatty acid transporter), member 5 ZNF499 19q13.43 zinc finger protein 499 TRIM28 5p13.3-p13.2 tripartite motif-containing 28
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2794 70.6 621 - 2000 10777669
    ZNF274a
    5 - 2589 62 548 - 2000 10777669
    ZNF274b
    8 - 2890 74.8 653 - 2000 10777669
    8 - 2905 - 611 - 2000 10777669
    ZNF274d
    7 - 2809 - 579 - 2000 10777669
    ZNF274e
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • at N terminus, two Krüppel associated box (KRAB)A domains, a KRAB domain which can bind the TRIM28 protein in a 1:3 ratio (KRAB:TRIM28) with KRAB at the center of the complex
  • a leucine rich region
  • five zinc finger motifs C2H2 type
  • one KRABA domain is missing in ZNF274b
  • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus,chromatin/chromosome
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • transcriptional repressor playing a role in the nucleolus
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • ZNF274 binding sites co-localize with SETDB1, TRIM28, and H3K9me3 at the 3prime ends of zinc finger genes
  • stimulation of the MAS1 protein should result in increased nitric oxide, potentially nitrating the ZNF274/TRIM28 complex,
  • resulting in dissociation of TRIM28 and activation of the transcription of MAS1
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS