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FLASH GENE
Symbol ZNF268 contributors: mct/npt - updated : 18-05-2011
HGNC name zinc finger protein 268
HGNC id 13061
Location 12q24.33      Physical location : 133.757.994 - 133.783.695
Synonym name zinc finger protein 3
Synonym symbol(s) HZF3, MGC126498
DNA
TYPE functioning gene
STRUCTURE 25.70 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site   cAMP
text structure
  • lacks a typical eukaryotic promoter that is present upstream of the transcription start site and directs a basal level of transcription
  • functional promoter requires an essential element that is located within the first exon of the gene (a cAMP response-element-binding protein (CREB)-binding site within this element for promoter function)
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 5756 108.4 947 expressed at relatively high levels in all samples 2006 16865230
  • ZNF268b1
  • having an in-frame stop codon near the 5'-end of exon 7
  • a KRAB domain
  • mainly observed in the cytoplasm
  • may function as transcriptional repressor
  • 4 - 560 - 68 in fetal liver and several tumor cell lines 2006 16865230
  • ZNF268e
  • lacks exons 4, 5 and 6
  • spacer domain and 24 C2H2 zinc finger motifs
  • 5 - 5629 - 167 . in tumor cell lines but not in fetal liver . expressed at low levels in brain, lung and small intestine, but was not detected in fetal heart 2006 16865230
  • ZNF268f
  • deleted of exons 3 and 4
  • spacer domain and 24 C2H2 zinc finger motifs
  • 4 - 5428 - 100 ubiquitous 2006 16865230
  • ZNF268g
  • 6 - 5632 108.4 947 expressed at relatively high levels in all samples 2006 16865230
  • ZNF268a
  • encodes a full length KRAB-containing zinc
  • finger protein
  • distributed diffusely throughout the cell
  • may function as transcriptional activator
  • 6 - 5639 98.8 864 only detected in tumor cells 2006 16865230
  • ZNF268c
  • spacer domain and 24 C2H2 zinc finger motifs
  • 4 - 5533 - 135 - 2006 16865230
  • ZNF268d
  • spacer domain and 24 C2H2 zinc finger motifs
  • 3 - - 88 - - 2006 16865230
  • spacer domain and 24 C2H2 zinc finger motifs (from
  • the initiation codon near the 5'-end of exon 7 to the stopcodon near the 3'-end of exon 7)
  • distributed diffusely throughout the cell
  • may function as transcriptional activator
  • 7 - 5862 22 193 - 2006 16865230
    6 - 5661 14.2 126 - 2006 16865230
    3 - 5332 97.8 863 - 2006 16865230
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumear   highly
    Reproductivemale systemtestis  highly
    Respiratoryrespiratory tracttrachea  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    Lymphoid/Immunemacrophage
    cell lineage
    cell lines monoblast cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text expressed in early embryos, predominantly, if not exclusively, in fetal liver with little detectable expression in other fetal organs
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a KRAB (Krüppel-associated box) at the N terminus
  • C terminal zinc finger motifs of the C2H2 type, Krüppel-like
  • conjugated MetalloP
    HOMOLOGY
    interspecies homolog to C. elegans Y25C1A.8
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome
    text localized mainly in the cytoplasm of embryonic hepatocytes
    basic FUNCTION
  • typical krueppel-associated box/C2H2 zinc finger gene involved in regulation of transcription, DNA-dependent
  • atypical and requiring an intragenic element located within the first exon that mediates the effect of CREB for its activity
  • plays a role in the differentiation of blood cells during early embryonic development and the pathogenesis of leukemia
  • plays a role in early liver development most likely by functioning through a cytoplasmic mechanism
  • may function as a transcriptional activator in the growth and differentiation of cells in development and/or pathogenesis
  • CELLULAR PROCESS nucleotide, transcription, regulation
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS development
    text hematopoiesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • IKK-interacting protein
  • cell & other
    REGULATION
    Other repressed in HTLV-1-infected cells
    regulated by UPF1 via its promoter
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS