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FLASH GENE
Symbol ZNF267 contributors: - updated : 27-02-2007
HGNC name zinc finger protein 267
HGNC id 13060
Location 16p11.1      Physical location : 31.885.078 - 31.928.626
Synonym symbol(s) HZF2
DNA
TYPE functioning gene
STRUCTURE 43.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter (CAAT box)
Binding site   transcription factor   cAMP
text structure
  • TATA-less promoter with multiple transcription initiation sites
  • CCAAT box, binding NF-Y within this region was essential for ZNF267 promoter activity
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    Lymphoid/Immunemacrophage
    cell lineage
    cell lines monoblast cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a zinc finger domain
  • a conserved KRAB (Kruppel associated box) A and B domain in the N-terminal part outside the C-terminal region of zinc fingers
  • a nuclear localization signal (NLS)
  • an Asp-Glu and a Ser-Arg rich regions
  • a zinc coordinating DNA binding domain
  • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY zinc finger protein family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • potential regulator of transcription and/or splicing
  • involved in the regulation of cell morphogenesis or cell identity
  • CELLULAR PROCESS nucleotide, transcription, maturation
    nucleotide, transcription, regulation
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS development
    text hematopoiesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    Zn2+
    protein repressing MMP10 gene expression (binds to the MMP10 promoter region)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in activated hepatic stellate cells and in cirrhotic liver
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS