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FLASH GENE
Symbol ZNF267 contributors: - updated : 27-02-2007
HGNC name zinc finger protein 267
HGNC id 13060
Location 16p11.1      Physical location : 31.885.078 - 31.928.626
Synonym symbol(s) HZF2
DNA
TYPE functioning gene
STRUCTURE 43.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter (CAAT box)
Binding site   transcription factor   cAMP
text structure
  • TATA-less promoter with multiple transcription initiation sites
  • CCAAT box, binding NF-Y within this region was essential for ZNF267 promoter activity
  • MAPPING cloned Y linked N status provisional
    Physical map
    FLJ13479 16p11.2 hypothetical protein FLJ13479 KIAA0296 16p13.13-p13.2 hypothetical protein FLJ13479 IMAGE3455200 BCKDK 16p11.2 branched chain alpha-ketoacid dehydrogenase kinase MYST1 16p11.2 MYST histone acetyltransferase 1 PRSS8 16p11.2 protease, serine, 8 (prostasin) FLJ90661 16p11.2 hypothetical protein FLJ90661 LOC390691 16 similar to Filamin B (FLN-B) (Beta-filamin) (Actin-binding like protein) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) (ABP-280 homolog) (ABP-278) (Filamin 3) (Filamin homolog 1) (Fh1) FUS 16p11.2 fusion, derived from t(12;16) malignant liposarcoma ASC 16p12-p11.2 fusion, derived from t(12;16) malignant liposarcoma PYC1 16p11.2 pyrin-domain containing protein 1 ITGAM 16p11.2 integrin, alpha M (complement component receptor 3, alpha; also known as CD11b (p170), macrophage antigen alpha polypeptide) ITGAX 16p11.2 integrin, alpha X (antigen CD11C (p150), alpha polypeptide) COX6A2 16p12-p11 cytochrome c oxidase subunit VIa polypeptide 2 MGC46336 16p11.2 hypothetical protein MGC46336 FLJ13063 16p11.2 hypothetical protein FLJ13063 TGFB1I1 16p11 transforming growth factor beta 1 induced transcript 1 SLC5A2 16p11.2 solute carrier family 5 (sodium/glucose cotransporter), member 2 FLJ13868 16p11.2 hypothetical protein FLJ13868 ERAF 16p11.1 erythroid associated factor LOC388247 16 similar to cold shock domain protein A; Cold-shock domain protein A LOC342426 16p11.2 similar to zinc finger protein 267; zinc finger (C2H2) MGC3020 16p11.2 hypothetical protein MGC3020 LOC124411 16p11.2 hypothetical protein LOC124411 VN1R3 16p11.2 vomeronasal 1 receptor 3 LOC390692 16 similar to hypothetical protein FLJ10290 ZNF267 16p11.1 zinc finger protein 267 LOC388248 16 similar to KIAA1501 protein LOC390693 16 similar to immunoglobulin heavy chain variable region LOC388249 16 similar to Ig heavy chain - human (fragment) LOC390694 16 similar to Ig H-chain V-region (DP-40) LOC390695 16 similar to protein kinase related to Raf protein kinases; Method: conceptual translation supplied by author LOC390696 16 similar to protein kinase related to Raf protein kinases; Method: conceptual translation supplied by author LOC388250 16 hypothetical gene supported by AB002391 LOC390697 16 similar to hypothetical protein MGC5244 LOC390698 16 LOC390698 LOC390699 16 similar to protein phosphatase 2A 48 kDa regulatory subunit; PP2A B LOC388251 16 LOC388251 LOC388252 16 similar to hypothetical protein LOC388253 16 similar to Adrenoleukodystrophy protein (ALDP)
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    Lymphoid/Immunemacrophage
    cell lineage
    cell lines monoblast cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a zinc finger domain
  • a conserved KRAB (Kruppel associated box) A and B domain in the N-terminal part outside the C-terminal region of zinc fingers
  • a nuclear localization signal (NLS)
  • an Asp-Glu and a Ser-Arg rich regions
  • a zinc coordinating DNA binding domain
  • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY zinc finger protein family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • potential regulator of transcription and/or splicing
  • involved in the regulation of cell morphogenesis or cell identity
  • CELLULAR PROCESS nucleotide, transcription, maturation
    nucleotide, transcription, regulation
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS development
    text hematopoiesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    Zn2+
    protein repressing MMP10 gene expression (binds to the MMP10 promoter region)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in activated hepatic stellate cells and in cirrhotic liver
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS