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FLASH GENE
Symbol ZNF263 contributors: SGE/npt - updated : 04-05-2009
HGNC name zinc finger protein 263
HGNC id 13056
Location 16p13.3      Physical location : 3.333.486 - 3.341.455
Synonym name
  • zinc finger protein FPM315
  • zinc finger protein with KRAB and SCAN domains 12
  • Synonym symbol(s) FPM315, ZKSCAN12
    DNA
    TYPE functioning gene
    STRUCTURE 7.97 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map pter - D16S521 - D16S3024 - ZNF263 - D16S3070 - D16S510 - D16S506 - D16S3128 - D16S418 - cen
    Authors Gene Map (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 3305 77.2 683 - Schumacher (2000)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
     thymus   highly
    Cardiovascularheart    
    Digestiveintestinesmall intestine   
     intestinelarge intestinecolon  
     liver    
    Endocrinepancreas    
    Nervousbrain    
    Reproductivefemale systemovary   
     male systemprostate   
     male systemtestis   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text placenta, tissues
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal SCAN box leucine-rich mediating self-association and oligomerization
  • a finger-associated structural motif
  • the A element of the Krüppel-associated box (KRAB)
  • nine zinc finger motifs C2H2 (Krüppel) type
  • secondary structure two alpha helices
    conjugated MetalloP
    HOMOLOGY
    interspecies homolog to murine Zfp263
    homolog to C.elegans F42G4.3A
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • SCAN subfamily
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • can have both positive and negative effects on transcriptional regulation of its target genes (Frietze 2010)
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS