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FLASH GENE
Symbol ZNF263 contributors: SGE/npt - updated : 04-05-2009
HGNC name zinc finger protein 263
HGNC id 13056
Location 16p13.3      Physical location : 3.333.486 - 3.341.455
Synonym name
  • zinc finger protein FPM315
  • zinc finger protein with KRAB and SCAN domains 12
  • Synonym symbol(s) FPM315, ZKSCAN12
    DNA
    TYPE functioning gene
    STRUCTURE 7.97 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map pter - D16S521 - D16S3024 - ZNF263 - D16S3070 - D16S510 - D16S506 - D16S3128 - D16S418 - cen
    Authors Gene Map (98)
    Physical map
    FLJ30002 16p13.3 hypothetical protein FLJ30002 KREMEN2 16p13.3 kringle containing transmembrane protein 2 PKMYT1 16p13.3 kringle containing transmembrane protein 2 LOC388205 16 similar to RIKEN cDNA 1520401A03 gene LOC388206 16 LOC388206 CLDN9 16p13.3 claudin 9 CLDN6 16p13.3 claudin 6 TNFRSF12A 16p13.3 tumor necrosis factor receptor superfamily, member 12A HCFC1R1 16p13.3 host cell factor C1 regulator 1 (XPO1 dependant) MGC2655 16p13.3 hypothetical protein MGC2655 LOC146439 16p13.3 similar to CDNA sequence BC038613 MMP25 16p13.3 matrix metalloproteinase 25 MMPL1 16p13.3 matrix metalloproteinase-like 1 NK4 16p13.3 matrix metalloproteinase-like 1 ZNF206 16p13.3 zinc finger protein 206 MGC3771 16p13.3 hypothetical protein MGC3771 ZNF205 16p13.3 zinc finger protein 205 ZNF213 16p13.3 zinc finger protein 213 LOC197350 16p13.3 hypothetical protein LOC197350 OR1F1 16p13.3 olfactory receptor, family 1, subfamily F, member 1 OR1F2 16p13.3 olfactory receptor, family 1, subfamily F, member 2 ZNF200 16p13.3 zinc finger protein 200 MEFV 16p13.3 Mediterranean fever FLJ39639 16p13.3 hypothetical protein FLJ39639 ZNF263 16p13.3 zinc finger protein 263 TIGD7 16p13.11 tigger transposable element derived 7 ZNF75A 16p13.11 zinc finger protein 75a LOC390670 16 similar to ribosomal protein L7-like 1 OR2C1 16p13.3 olfactory receptor, family 2, subfamily C, member 1 ZNF434 16p13.3 zinc finger protein 434 ZNF174 16p13.3 zinc finger protein 174 FLJ33071 16p13.3 hypothetical protein FLJ33071 LOC388207 16 LOC388207 FLJ14154 16p13.3 hypothetical protein FLJ14154 LOC390671 16 similar to ribosomal protein L18; 60S ribosomal protein L18 KIAA0643 16p13.3 similar to ribosomal protein L18; 60S ribosomal protein L18 NOD3 16p13.3 NOD3 protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 3305 77.2 683 - Schumacher (2000)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
     thymus   highly
    Cardiovascularheart    
    Digestiveintestinesmall intestine   
     intestinelarge intestinecolon  
     liver    
    Endocrinepancreas    
    Nervousbrain    
    Reproductivefemale systemovary   
     male systemprostate   
     male systemtestis   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text placenta, tissues
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal SCAN box leucine-rich mediating self-association and oligomerization
  • a finger-associated structural motif
  • the A element of the Krüppel-associated box (KRAB)
  • nine zinc finger motifs C2H2 (Krüppel) type
  • secondary structure two alpha helices
    conjugated MetalloP
    HOMOLOGY
    interspecies homolog to murine Zfp263
    homolog to C.elegans F42G4.3A
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • SCAN subfamily
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • can have both positive and negative effects on transcriptional regulation of its target genes (Frietze 2010)
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS