Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ZNF260 contributors: mct - updated : 20-08-2011
HGNC name zinc finger protein 260
HGNC id 13499
Location 19q13.12      Physical location : 37.001.589 - 37.019.248
Synonym name
  • phenylephrine-induced complex-1
  • Synonym symbol(s) OZRF1, PEX1, ZFP260
    DNA
    TYPE functioning gene
    STRUCTURE 17.66 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 5341 - 412 - 2011 21051538
    3 - 5360 - 412 - 2011 21051538
    4 - 5468 - 412 - 2011 21051538
    4 - 5474 - 412 - 2011 21051538
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Respiratorylung     Homo sapiens
    Urinarykidney     Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularsmooth  highly Homo sapiens
    Muscularstriatumcardiac highly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text highly expressed in the embryonic heart
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 13-zinc finger
  • HOMOLOGY
    Homologene
    FAMILY Krüppel family of transcriptional regulators
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • transcriptional regulator in normal and pathological heart development and a nuclear effector of alpha1-adrenergic signaling
  • essential for cardiomyocyte response to EDN1
  • may be a regulator of the early stages of cardiac hypertrophy
  • may be a nuclear effector of other growth-promoting stimuli
  • role for ZNF260 and GATA4 as mutual coactivators of a genetic program underlying cardiac hypertrophy
  • may be a critical effector of neurohormonal signaling activated during early stages of hypertrophy
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of a transcriptional complex that governs early events in cardiac hypertrophy
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • transcriptional activator of NPPA and a cofactor for GATA4, a key cardiac regulator
  • cell & other
    REGULATION
    induced by alpha1-adrenergic agonists
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    is sufficient to induce cardiomyocyte hypertrophy
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS