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FLASH GENE
Symbol ZNF254 contributors: np - updated : 02-09-2005
HGNC name zinc finger protein 254
HGNC id 13047
Location 19p13.12-p13.11      Physical location : 24.269.975 - 24.312.652
Synonym name
  • zinc finger protein 539
  • bone marrow zinc finger 5
  • hematopoietic cell-derived zinc finger protein 1
  • zinc finger protein 91-like
  • Synonym symbol(s) BMZF-5, ZNF91L, HD-ZNF1, BMZF5, ZNF539
    DNA
    TYPE functioning gene
    STRUCTURE 42.00 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC163223 19p13.11 similar to Zinc finger protein 208 LOC342994 19p13.11 similar to ribosomal protein L34; 60S ribosomal protein L34 LOC148198 19p13.11 similar to Zinc finger protein 492 LOC342999 19p13.11 similar to ZNF43 protein LOC374890 19p13.11 hypothetical gene supported by BC030765 ZNF492 19p13.11 zinc finger protein 492 LOC390906 19 similar to Zinc finger protein 492 LOC126502 19p13.11 similar to zinc finger protein 91 (HPF7, HTF10) LOC388523 19 similar to Zinc finger protein 208 LOC126506 19p13.11 sorting nexin 6 pseudogene ZNF91 19p12 zinc finger protein 91 (HPF7, HTF10) LOC253342 19p13.11 similar to zinc finger protein 91 (HPF7, HTF10) LOC390908 19 similar to zinc finger protein 91 (HPF7, HTF10) TIZ 19p11 similar to zinc finger protein 91 (HPF7, HTF10) LOC148213 19p12 hypothetical protein FLJ31526 LOC388524 19 similar to 40S ribosomal protein SA (P40) (34/67 kDa laminin receptor) (Colon carcinoma laminin-binding protein) (NEM/1CHD4) (Multidrug resistance-associated protein MGr1-Ag) LOC388525 19 similar to zinc finger protein 91 (HPF7, HTF10) LOC390909 19 similar to ZNF273 protein LOC390910 19 similar to Gag-Pro-Pol protein LOC390911 19 similar to zinc finger protein 91 (HPF7, HTF10) LOC390912 19 similar to Zinc finger protein 93 (Zinc finger protein HTF34) LOC390913 19 similar to Zinc finger protein 254 (Bone marrow zinc finger 5) (BMZF-5) (Hematopoietic cell derived zinc finger protein 1) (HD-ZNF1) LOC390914 19 similar to cytochrome P450 monooxygenase ZNF254 19p13.12-p13.11 zinc finger protein 254 LOC163213 19p12 similar to hepatitis A virus cellular receptor 1; T cell immunoglobin domain and mucin domain protein 1; kidney injury molecule 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 3986 77 659 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systembreastmammary gland moderately
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneT cell null (stem cell)
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a KRAB (Krüppel associated box) domain
  • three C2H2 zinc finger domains
  • conjugated MetalloP
    HOMOLOGY
    interspecies ortholog to chimpanzee ZNF93
    intraspecies homolog to ZNF91
    Homologene
    FAMILY
  • Kruppel family of C2H2-type zinc finger proteins
  • KRAB subfamily
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • repressing transcription
  • involved in regulation of transcription
  • CELLULAR PROCESS nucleotide, transcription, regulation
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS development
    text hematopoiesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS