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FLASH GENE
Symbol ZNF253 contributors: - updated : 11-03-2006
HGNC name zinc finger protein 253
HGNC id 13497
Location 19p13.1      Physical location : 19.976.713 - 20.004.292
Synonym name
  • bone marrow zinc finger 1
  • zinc finger protein 411
  • Synonym symbol(s) BMZF1, BMZF-1, FLJ90391, ZNF411
    DNA
    TYPE functioning gene
    STRUCTURE 27.00 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    HOMER3 19p13.11 homer homolog 3 (Drosophila) SFRS14 19p12-p11 splicing factor, arginine/serine-rich 14 MGC19595 19p13.11 hypothetical gene MGC19595 MGC26694 19p13.11 hypothetical protein MGC26694 FLJ20422 19p13.11 hypothetical protein FLJ20422 MEF2B 19p12 MADS box transcription enhancer factor 2, polypeptide B (myocyte enhancer factor 2B) RFXANK 19p12 regulatory factor X-associated ankyrin-containing protein TRA16 19p13.11 TR4 orphan receptor associated protein TRA16 CSPG3 19p12 chondroitin sulfate proteoglycan 3 (neurocan) TM6SF2 19p13.3-p12 transmembrane 6 superfamily member 2 SF4 19p13 splicing factor 4 KIAA0892 19p13.11 KIAA0892 p66alpha 19p13.11 p66 alpha CLIP-2 19p13.11 cartilage intermediate layer protein-like protein 2 SSTK 19p13.11 serine/threonine protein kinase SSTK GRIM19 19p13.2 serine/threonine protein kinase SSTK FLJ44968 19p13.11 FLJ44968 protein PBX4 19p12 pre-B-cell leukemia transcription factor 4 EDG4 19p12 endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 4 GMIP 19p11-p12 Gem-interacting protein CGI-152 HZF12 ZNF14 19p13.3-p13.2 zinc finger protein 14 (KOX 6) LOC390898 19 similar to sorting nexin associated golgi protein 1 MGC39821 19p13.11 hypothetical protein MGC39821 ZNF506 19p13.11 zinc finger protein 506 LOC390899 19 similar to hypothetical protein FLJ12488 ZNF253 19p13.1 zinc finger protein 253 ZNF505 19p13.11 zinc finger protein 505 LOC91120 19p13.11 hypothetical ZNF-like protein ZNF90 19p13.1-p12 zinc finger protein 90 (HTF9) LOC388519 19 similar to 40S ribosomal protein S16 ZNF486 19p13.11 zinc finger protein 486 LOC284441 19p13.11 similar to actin-related protein 2 LOC390900 19 similar to hypothetical protein FLJ12488 LOC388520 19 hypothetical gene supported by AK126842 LOC163233 19p13.11 similar to Zinc finger protein 93 (Zinc finger protein HTF34) LOC390901 19 similar to Zinc finger protein 431 LOC199777 19p13.11 similar to DNA-binding protein; zinc finger protein 253 LOC390902 19 similar to Zinc finger protein 93 (Zinc finger protein HTF34) LOC390903 19 similar to Zinc finger protein 93 (Zinc finger protein HTF34)
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
    Lymphoid/Immunethymus   highly
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmature hematopoietic
    cell lineage monocytic and immature erythroid cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text skeletal muscle, heart, and pancreas, placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a KRAB (Krüppel associated box) domain
  • eleven C2H2 zinc finger domains at the C-terminus
  • conjugated MetalloP
    HOMOLOGY
    intraspecies homolog to ZNF92
    Homologene
    FAMILY Kruppel family of C2H2-type zinc finger proteins
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • mediating transcriptional repression
  • may be involved in the heart development, and it probably works as a negative regulator in MAPK signaling pathway
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS