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FLASH GENE
Symbol ZNF24 contributors: mct/npt - updated : 18-11-2009
HGNC name zinc finger protein 24
HGNC id 13032
Location 18q12.2      Physical location : 32.912.177 - 32.924.426
Synonym name
  • zinc finger protein 24 (KOX 17)
  • retinoic acid suppression protein A
  • zinc finger and SCAN domain-containing protein 3
  • zinc finger protein 191
  • lacks zinc finger domain
  • Synonym symbol(s) KOX17, ZNF191, RSGA, ZSCAN3, Zfp191
    DNA
    TYPE functioning gene
    STRUCTURE 12.25 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 6311 - 368 - Zhao (2007)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneT cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text expressed in progenitors of the developing CNS (Khalfallah 2009)
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • in its N-terminus, a SCAN box leucine rich, involved in self-association and oligomerization with typical transcriptional regulatory motifs
  • in its C-terminus, four C2H2 type, Krüppel-like domains
  • conjugated MetalloP
    HOMOLOGY
    interspecies homolog to murine Zfp191
    homolog to C.elegans y54e10br.a
    Homologene
    FAMILY
  • SCAN domain family of Krüppel-like zinc finger transcription factors
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in the suppression of transcription
  • indispensable for early embryonic development and cell proliferation (Li 2006)
  • involved in negative regulation of VEGF and may represent a novel repressor of VEGF transcription (Harper 2007)
  • displays a suppressive effect on the transcription (Li 2009)
  • a pleiotropic factor that has a role in hematopoiesis, brain development and cancers (Li 2009)
  • essential factor acting for the promotion of the cell cycle and thus maintenance in the progenitor stage (Khalfallah 2009)
  • required for the myelinating function of differentiated oligodendrocytes (Howng 2010)
  • required for the conversion of oligodendrocytes from the premyelinating to the myelinating state (Howng 2010)
  • involved in negative regulation of PDGFRB via its interaction with MYC and may represent a novel repressor of PDGFRB transcription
  • involved in negative regulation of vascular endothelial growth factor (VEGF) and may represent a novel repressor of VEGF transcription
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • can specifically interact with the widespread TCAT motif which constitutes the HUMTH01 microsatellite in the tyrosine hydroxylase (TH) gene (Li 2009)
  • may repress VEGF transcription (Harper 2007)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --other  
    misexpression maintains progenitors in cycle and exerts negative control on the Notch pathway, which prevents them from differentiating (Khalfallah 2009)
    tumoral     --over  
    in angiogenic tumor nodules where VEGF expression is significantly decreased compared with preangiogenic nodules (Harper 2007)
    tumoral     --over  
    in breast carcinoma (Harper 2007)
    tumoral     --low  
    in ovarian malignant tumors, malignant colon and breast carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS