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FLASH GENE
Symbol ZNF238 contributors: - updated : 04-07-2007
HGNC name zinc finger protein 238
HGNC id 13030
Corresponding disease
DEL1Q44 chromosome 1q44 microdeletion syndrome
Location 1q44-qter      Physical location : 244.214.560 - 244.220.776
Synonym name
  • 58 kDa repressor protein
  • translin-associated zinc finger protein 1
  • zinc finger and BTB domain-containing protein 18
  • zinc finger protein C2H2-171
    • Synonym symbol(s) RP58,TAZ-1, C2H2-171, ZBTB18
    DNA
    TYPE functioning gene
    STRUCTURE 6.00 kb     2 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Map cen - D1S2693 - ADSS - ZNF238 - D1S423 - qter
    Authors Gene Map (98)
    Physical map
    LOC388755 1 LOC388755 FH 1q42.1 fumarate hydratase KMO 1q42-q44 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) OPN3 1q43 opsin 3 (encephalopsin, panopsin) CHML 1q32-q41 choroideremia-like (Rab escort protein 2) FLJ32978 1q43 hypothetical protein FLJ32978 LOC391181 1 similar to 60S ribosomal protein L6 (TAX-responsive enhancer element binding protein 107) (TAXREB107) (Neoplasm-related protein C140) EXO1 1q43 exonuclease 1 LOC391182 1 similar to 60S ribosomal protein L23a FLJ40773 1q43 hypothetical protein FLJ40773 LOC391183 1 similar to ribosomal protein L24-like; 60S ribosomal protein L30 isolog; my024 protein; homolog of yeast ribosomal like protein 24 LOC391184 1 similar to RCC1-like LOC343365 1q43 similar to capicua homolog LOC388756 1 similar to hypothetical protein LOC349114 LOC388757 1 LOC388757 LOC339077 1q43 hypothetical gene supported by AK092558; AL137655; BC006361 KAB 1q44 KARP-1-binding protein SDCCAG8 1q44 serologically defined colon cancer antigen 8 AKT3 1q43-q44 v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) LOC388758 1 LOC388758 LOC339529 1q44 hypothetical protein LOC339529 ZNF238 1q44-qter zinc finger protein 238 LOC343484 1q44 hypothetical LOC343484 LOC200159 1q44 hypothetical LOC200159 LOC126826 1q44 similar to TGFB-induced factor 2; TGF(beta)-induced transcription factor 2; transcription growth factor-beta-induced factor 2; homeobox protein TGIF2; 5-TG-3 interacting factor 2 ADSS 1cen-q12 adenylosuccinate synthase MGC33370 1q44 hypothetical protein MGC33370 HCP5 6p21.3 HLA complex P5 PNAS-4 1q44 CGI-146 protein LOC116228 1q44 hypothetical protein LOC116228 HNRPU 1q44 heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) MGC12458 1q44 hypothetical protein MGC12458 MGC35030 1q44 hypothetical protein MGC35030 FLJ10157 1q44 hypothetical protein FLJ10157 SMYD3 1q44 SET and MYND domain containing 3 LOC255654 1q44 hypothetical protein LOC255654 TFB2M 1q44 transcription factor B2, mitochondrial FLJ32001 1q44 hypothetical protein FLJ32001 CGI-49 1q44 CGI-49 protein LOC391185 1 similar to kinesin-like protein (103.5 kD) (klp-6) ELYS 1q44 ELYS transcription factor-like protein TMBS62 SBZF3 1q44 zinc finger protein SBZF3 MGC12466 1q44 hypothetical protein MGC12466
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 3898 - 531 - Gregory
    - - 4244 58.3 522 - Gregory
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveintestinesmall intestine  highly
    Nervousbrainhindbraincerebellum highly
     nerve   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a BTB/POZ zinc finger N terminal domain
  • four zinc finger-like domains at the C terminus
    • conjugated MetalloP
    HOMOLOGY
    interspecies homolog to murine Znf238
    Homologene
    FAMILY zinc finger protein family, C2H2 type
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • playing a role in transcriptional repression in the central nervous system
  • may play an important role in brain development and function
    • CELLULAR PROCESS cell life
    nucleotide, transcription, regulation
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    Zn2+
    protein recruiting DNMT3A to HDAC1 to silence transcription
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL1Q44
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS