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FLASH GENE
Symbol ZNF224 contributors: mct/npt/pgu - updated : 17-02-2010
HGNC name zinc finger protein 224
HGNC id 13017
Location 19q13.31      Physical location : 44.598.481 - 44.612.477
Synonym name
  • zinc finger protein 255
  • zinc finger 2, bone marrow
  • zinc finger protein 27 (KOX 22)
  • zinc finger protein 233
  • Synonym symbol(s) BMZF2, ZNF255, BMZF2, KOX22, ZNF27, ZNF233
    DNA
    TYPE functioning gene
    STRUCTURE 13.98 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2466 - 707 - 2010 20591825
  • nuclear interaction between ZNF224 and WT1(&
  • 8722;KTS) results in an increase in trascriptional activation mediated by WT1, implying that ZNF224 acts as a co-regulator of WT1
    - splicing - - 622 . in fetal brain, kidney, muscle . distributed throughout the cell and is present also in nucleoli and cytosol 2007 17900823
  • spans the region between amino acids 86 and 707 of ZNF224
  • having 19 zinc-finger domains of ZNF224, lacks the KRAB A domain and possesses a KRNB located at its amino terminus, which may function as a transregulatory domain
  • potential role in RNA processing together with WT1
  • involvement in a specific molecular pathway, RNA maturation and processing
  • interacts and co-localizes with both WT1 isoforms, with a preference for the (+KTS) isoform, suggesting a role for this interaction in RNA maturation and post-transcriptional control
  • ZNF224 and ZNF255 have a distinct pattern of distribution within the cell and display a specific pattern of interaction with different molecular partners.
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumearinnercochlea highly
    Lymphoid/Immunethymus   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Muscularstriatum  highly
    cell lineage
    cell lines Hela cells
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a Krüppel-associated box (KRAB) domain at the NH2 terminus, including a canonical box A and a degenerated box b
  • one KRAB domain
  • 19 Cys2-His2 zinc-finger domains at the C-terminus
  • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • KRAB-ZFP family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    text homogenous nuclear distribution
    basic FUNCTION
  • represses aldolase A gene transcription by interacting with the TRIM28 co-repressor protein
  • repressing the transcription of the SLC25A1 gene and so may be responsible for the low expression of SLC25A1 in fetal tissues in which fatty acid synthesis is low
  • with its shorter isoform, ZNF255, differentially repress aldolase gene transcription and exhibit a distinctive subcellular localization
  • may act as a transcriptional co-regulator of WT1(&
  • 8722;KTS)
  • multifunctional protein and the alternative splicing, sub-cellular compartmentalization and isoform-specific interactions may modulate its activity
  • ZNF224 can be a mediator of DNA damage-induced apoptosis in leukemia cells
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • direct interaction between the arginine methyltransferase PRMT5 and ZNF224 is required for repression of aldolase A gene transcription
  • WT1-associating protein
  • binding to the cis-negative regulatory element of aldolase A (AldA-NRE), and transcriptional repressor of the human aldolase A gene
  • PRMT5 was demonstrated to play a crucial role in the transcriptional ZNF224 repressor complex
  • acts in fine tuning of WT1-dependent control of gene expression, acting as a co-activator of WT1 in the regulation of proapoptotic genes and suppressing WT1 mediated trans-activation of antiapoptotitc genes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS