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FLASH GENE
Symbol ZNF22 contributors: mct - updated : 25/10/2008
HGNC name zinc finger protein 22 (KOX 15)
HGNC id 13012
Location 10q11.2      Physical location : 45.496.272 - 45.500.776
Synonym symbol(s) Krox-26, HKR-T1, KOX15, ZNF422, Zfp422
DNA
TYPE like-sequence
STRUCTURE 4.85 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Physical map
FXYD4 10q11.21 FXYD domain containing ion transport regulator 4 HNRPF 10q11.21-q11.22 heterogeneous nuclear ribonucleoprotein F LOC283031 10q11.21 hypothetical protein LOC283031 ZNF239 10q11.22-q11.23 zinc finger protein 239 LOC387660 10 hypothetical gene supported by M98474 LOC220992 10q11.21 Zinc finger protein 93 (Zinc finger protein HTF34) ZNF32 10q23-q24 zinc finger protein 32 (KOX 30) HNRPA3 10p11.1 heterogeneous nuclear ribonucleoprotein A3 LOC283034 10q11.21 hypothetical LOC283034 CXCL12 10q11.2 chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) LOC387661 10 similar to ribosomal protein L9; 60S ribosomal protein L9 LOC387662 10 hypothetical gene supported by BX538120 RASSF4 10q11.21 Ras association (RalGDS/AF-6) domain family 4 C10orf10 10q11.21 chromosome 10 open reading frame 10 C10orf25 10q11.21 chromosome 10 open reading frame 25 ZNF22 10q11.2 zinc finger protein 22 (KOX 15) LOC340765 10q11.21 similar to double homeobox, 4; double homeobox protein 4 LOC387663 10 similar to cubilin; intrinsic factor-cobalamin receptor; intrinsic factor B12-receptor LOC389957 10 similar to breast cancer antigen NY-BR-1.1 LOC389958 10 similar to cubilin; intrinsic factor-cobalamin receptor; intrinsic factor B12-receptor LOC220974 10q11.21 similar to olfactory receptor GA_x54KRFPKN04-58149882-58150865 OR13A1 10q22.2 olfactory receptor, family 13, subfamily A, member 1 ALOX5 10q11.2 arachidonate 5-lipoxygenase MIR 10q11.22 c-mir, cellular modulator of immune recognition LOC387664 10 LOC387664 ANUBL1 10q11.22 AN1, ubiquitin-like, homolog (Xenopus laevis) LOC143158 10q11.22 similar to ARF GTPase-activating protein LOC389959 10 similar to KIAA0592 protein KIAA0592 10q11.1 KIAA0592 protein MRIP2 10q11.22 ARF GTPase-activating protein LOC389960 10 hypothetical gene supported by AY258587; NM_003631 LOC387665 10 similar to ARF GTPase-activating protein LOC387666 10 similar to Ribosome biogenesis protein BMS1 homolog LOC389961 10 hypothetical gene supported by L25628 RHEBP1 10q11 Ras-homolog enriched in brain pseudogene 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 2204 - 204 - Gao (2003)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestivepharynx   highly
Hearing/Equilibriumear   highly
Lymphoid/Immunelymph node   highly
Nervousbrain    
Reproductivemale systemprostate   
Urinarybladder    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Muscularstriatumcardiac  
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneT cell
cell lineage
cell lines
fluid/secretion
at STAGE
Text in the epithelial component of the developing tooth organ during early bud and cap stages as well as in osteoblasts of craniofacial bone and the developing tongue
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
five zinc finger motif, C2H2 type, Krüppel-like
conjugated MetalloP
HOMOLOGY
interspecies ortholog to murine Krox-26
Homologene
FAMILY zinc finger protein family, C2H2 type, Krüppel-like
CATEGORY regulatory , transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,chromatin/chromosome
basic FUNCTION
  • may be involved in transcriptional regulation and may play a role in tooth formation
  • potential regulator of tooth formation
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    Zn2+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene for STHAG5
    Marker
    Therapy target
    ANIMAL & CELL MODELS