basic FUNCTION
| transcriptional repressor protein that functions, at least in part, by associating with CTBP1 |
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may play roles in both early- and late-stage breast cancer and can attenuate apoptotic signals resulting from telomere dysfunction as well as from doxorubicin-induced DNA damage |
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may promote neoplastic transformation by increasing cell survival during telomeric crisis and later stages of malignancy by increasing cell survival during chemotherapy |
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implicated with its associated proteins in a novel pathway that may have profound effects on cancer progression |
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transcriptional repressor protein, having, with its associated proteins in a novel pathway, profound effects on cancer progression |
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key factor in regulating ovarian cancer proliferation and progression |
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assembles a distinct set of histone modifying proteins at target DNA sites that act synergistically in transcriptional repression |
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regulates expression of the ERBB3 receptor tyrosine kinase in breast cancer cells |
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implicated as an oncogene and in repressing the E-cadherin gene |
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disruption of active demethylation by the ZNF217 oncogene may be a paradigm for other oncogenic signals on DNA methylation dynamics |
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promoted epithelial-mesenchymal transition (EMT) in mammary epithelial cells, and the TGFB1-activated Smad signaling pathway was identified as a major driver of ZNF217-induced EMT |
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alternatively spliced Kruppel-like transcription factor that has recently been implicated to play a role in carcinogenesis |
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may contribute to ovarian cancer invasion and metastasis, and is associated with worse clinical outcomes |
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orchestrates complex intracellular circuits as a new key regulator of tumorigenesis |