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FLASH GENE
Symbol ZNF208 contributors: mct/npt - updated : 07-04-2010
HGNC name zinc finger protein 208
HGNC id 12999
Location 19p12      Physical location : 22.148.898 - 22.193.745
Synonym name
  • zinc finger protein 95 (F13463)
  • KRAB only
  • Synonym symbol(s) PMIDP, ZNF95, ZNF91L, KRAB-O
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text member of a cluster of zinf finger genes
    STRUCTURE 44.85 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map pter - ZNF209 - D19S454 - D19S439 - D19S215 - D19S438 - D19S269 - ZNF208 - D19S459 - D19S455 - cen
    Authors Eichler (98)
    Physical map
    LOC284441 19p13.11 similar to actin-related protein 2 LOC390900 19 similar to hypothetical protein FLJ12488 LOC388520 19 hypothetical gene supported by AK126842 LOC163233 19p13.11 similar to Zinc finger protein 93 (Zinc finger protein HTF34) LOC390901 19 similar to Zinc finger protein 431 LOC199777 19p13.11 similar to DNA-binding protein; zinc finger protein 253 LOC390902 19 similar to Zinc finger protein 93 (Zinc finger protein HTF34) LOC390903 19 similar to Zinc finger protein 93 (Zinc finger protein HTF34) LOC342991 19p13.11 similar to hypothetical protein FLJ12488 ZNF85 19p12 zinc finger protein 85 (HPF4, HTF1) LOC390904 19 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) ZNF430 19p12 zinc finger protein 430 ZNF431 19p12 zinc finger protein 431 LOC148203 19p13.11 hypothetical protein LOC148203 LOC388521 19 similar to hypothetical protein LOC390905 19 similar to hypothetical protein LOC163227 LOC115648 19p13.11 similar to hypothetical protein FLJ13659 ZNF493 19p13.11 zinc finger protein 493 LOC388522 19 similar to Zinc finger protein 429 LOC163227 ZNF43 19p13.1-p12 zinc finger protein 43 (HTF6) ZNF208 19p12 zinc finger protein 208 ZNF257 19q13 zinc finger protein 257 LOC253272 19p13.11 ring finger protein 134 pseudogene LOC163223 19p13.11 similar to Zinc finger protein 208 LOC342994 19p13.11 similar to ribosomal protein L34; 60S ribosomal protein L34 LOC148198 19p13.11 similar to Zinc finger protein 492 LOC342999 19p13.11 similar to ZNF43 protein LOC374890 19p13.11 hypothetical gene supported by BC030765 ZNF492 19p13.11 zinc finger protein 492 LOC390906 19 similar to Zinc finger protein 492 LOC126502 19p13.11 similar to zinc finger protein 91 (HPF7, HTF10) LOC388523 19 similar to Zinc finger protein 208 LOC126506 19p13.11 sorting nexin 6 pseudogene ZNF91 19p12 zinc finger protein 91 (HPF7, HTF10) LOC253342 19p13.11 similar to zinc finger protein 91 (HPF7, HTF10) LOC390908 19 similar to zinc finger protein 91 (HPF7, HTF10)
    regionally located in a cluster of Krüppel associated box zinc finger
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 9088 - 1280 - Eichler (1998)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneT cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • zinc finger protein
  • a N terminal KRAB (Krüppel associate box) domain, functioning as a transcriptional repression module
  • a several zinc fingers DNA-binding domain
  • conjugated MetalloP
    HOMOLOGY
    interspecies homolog to murine Zfp208
    Homologene
    FAMILY
  • zinc finger protein family, C2H2 type
  • KRAB subfamily, F13463 type
  • CATEGORY regulatory , DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in transcriptional repression
  • important role for ZNF208 and other KRAB-ZNF genes in mediating SRY function (Peng 2009)
  • function as a bridging molecule between TRIM28 and SRY proteins (Peng 2009)
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component SRY, ZNF208/KRAB, and TRIM28 proteins formed a stable ternary protein complex (Peng 2009)
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    Zn2+
    protein
  • SRY (sex-determining region Y)-interacting protein (Peng 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS