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FLASH GENE
Symbol ZNF208 contributors: mct/npt - updated : 07-04-2010
HGNC name zinc finger protein 208
HGNC id 12999
Location 19p12      Physical location : 22.148.898 - 22.193.745
Synonym name
  • zinc finger protein 95 (F13463)
  • KRAB only
  • Synonym symbol(s) PMIDP, ZNF95, ZNF91L, KRAB-O
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text member of a cluster of zinf finger genes
    STRUCTURE 44.85 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map pter - ZNF209 - D19S454 - D19S439 - D19S215 - D19S438 - D19S269 - ZNF208 - D19S459 - D19S455 - cen
    Authors Eichler (98)
    regionally located in a cluster of Krüppel associated box zinc finger
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 9088 - 1280 - Eichler (1998)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneT cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • zinc finger protein
  • a N terminal KRAB (Krüppel associate box) domain, functioning as a transcriptional repression module
  • a several zinc fingers DNA-binding domain
  • conjugated MetalloP
    HOMOLOGY
    interspecies homolog to murine Zfp208
    Homologene
    FAMILY
  • zinc finger protein family, C2H2 type
  • KRAB subfamily, F13463 type
  • CATEGORY regulatory , DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in transcriptional repression
  • important role for ZNF208 and other KRAB-ZNF genes in mediating SRY function (Peng 2009)
  • function as a bridging molecule between TRIM28 and SRY proteins (Peng 2009)
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component SRY, ZNF208/KRAB, and TRIM28 proteins formed a stable ternary protein complex (Peng 2009)
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    Zn2+
    protein
  • SRY (sex-determining region Y)-interacting protein (Peng 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS