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FLASH GENE
Symbol ZNF197 contributors: - updated : 04-09-2006
HGNC name zinc finger protein 197
HGNC id 12988
Location 3p21.2-p21.1      Physical location : 44.666.510 - 44.689.962
Synonym name
  • VHL-associated KRAB-A domain-containing protein
  • zinc finger protein 20
  • Synonym symbol(s) D3S1363E, ZNF20, P18, VHLaK, ZNF166
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text located in a cluster of zinc finger genes at 3p21
    STRUCTURE 16.00 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map pter - D3S1620 - ACAA1 - D3S3687 - D3S3685 - D3S3559 - D3S3564 - ZNF35 - ZNF197 - D3S3582 - cen
    Authors Gene Map (98)
    Physical map
    ABHD5 3p21.32-p21.31 abhydrolase domain containing 5 FLJ36157 3p21.32 FLJ36157 protein DKFZp313N0621 3p21.32 hypothetical protein DKFZp313N0621 LOC285344 3p21.32 similar to hypothetical protein MG11009.4 ZNF445 3p21.32 zinc finger protein 445 LOC285346 3p21.32 hypothetical protein LOC285346 ZNF167 3p22-p21 zinc finger protein 167 LOC389115 3 hypothetical gene supported by BC009982; NM_015134 FLJ36870 3p21.32 hypothetical protein FLJ36870 ZNF197 3p21.2-p21.1 zinc finger protein 197 ZNF35 3p21 zinc finger protein 35 (clone HF.10) LOC391531 3 similar to zinc finger protein 347; zinc finger 1111 LOC389116 3 hypothetical gene supported by AL136896; NM_014011 ZNF502 3p21.32 zinc finger protein 502 ZNF501 3p21.32 zinc finger protein 501 KIAA1143 3p21.32 KIAA1143 protein KNSL7 3p21.33 kinesin-like 7 MGC29956 3p21.32 hypothetical protein MGC29956 LOC391532 3 similar to peptidyl-Pro cis trans isomerase TGM4 3p22-p21.3 transglutaminase 4 (prostate) FLJ20209 3p21.32 hypothetical protein FLJ20209 ZDHHC3 3p21.32 zinc finger, DHHC domain containing 3 KIAA0116 3p21 Homo sapiens KIAA0116 protein (KIAA0116), mRNA. TNA 3p21.3 tetranectin (plasminogen binding protein) CDCP1 3p24.3-p22.1 tetranectin (plasminogen binding protein) RIS1 3p21.3 tetranectin (plasminogen binding protein) LARS2 3p21.3 leucyl-tRNA synthetase 2, mitochondrial
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 4338 - 1029 - Li
    - - 2965 - 267 - Li
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Endocrinethyroid   highly
    Reproductivefemale systemuteruscervix highly
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal KRAB (Kruppel-associated box) domain
  • a SCAN box, leucine-rich, mediating self-association and oligomerization
  • 22 tandemly arrayed C2H2-type zinc fingers
  • conjugated MetalloP
    HOMOLOGY
    interspecies homolog to Drosophila CG6654
    homolog to C.elegans B0524.1
    Homologene
    FAMILY krueppel C2H2-type zinc-finger protein family
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION may be involved in transcriptional regulation
    CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in some thyroid papillary carcinomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS