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FLASH GENE
Symbol ZNF185 contributors: mct/npt - updated : 01/12/2008
HGNC name zinc finger protein 185 (LIM domain)
HGNC id 12976
Location Xq28      Physical location : 152.082.985 - 152.142.024
Synonym name LIM domain protein ZNF185
Synonym symbol(s) P1-A
DNA
TYPE functioning gene
STRUCTURE 59.03 kb     23 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
GABRQ Xq28 gamma-aminobutyric acid (GABA) receptor, theta TRAG3 Xq28 taxol resistance associated gene 3 MAGEA2b Xq28 melanoma antigen, family A, 2, copy b MAGEA12 Xq28 melanoma antigen, family A, 12 CSAGE Xq28 chondrosarcoma associated gene 1 MAGEA2 Xq28 melanoma antigen, family A, 2 LOC389903 X similar to Taxol resistant associated protein 3 (TRAG-3) MAGEA3 Xq28 melanoma antigen, family A, 3 MAGEA6 Xq28 melanoma antigen, family A, 6 psMAGEA Xq28 melanoma antigen pseudogene, family A CETN2 Xq28 centrin, EF-hand protein, 2 H105E3 Xq28 centrin, EF-hand protein, 2 ZNF185 Xq28 zinc finger protein 185 (LIM domain) PNMA5 Xq28 paraneoplastic antigen like 5 PNMA3 Xq28 paraneoplastic antigen MA3 MGC15827 Xq28 hypothetical protein MGC15827 MAGEA1 Xq28 melanoma antigen, family A, 1 (directs expression of antigen MZ2-E) LOC139046 Xq28 similar to hypothetical protein MGC15827 ZNF275 Xq28 zinc finger protein 275 LOC392559 X similar to hypothetical protein MGC15827 LOC139735 Xq28 similar to zinc finger protein 92 TREX2 Xq28 three prime repair exonuclease 2
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
23 - 4312 73.4 689 - Zhang (2007)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth   highly
Endocrineneuroendocrinepituitary  highly
Reproductivefemale systemovary   
 male systemtestis   
 male systemprostate   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
Connective    
Epithelialsecretoryglandularendocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, fetal, pregnancy
Text placenta, kidney
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two N-terminal cysteine-rich LIM/double zinc finger motifs (LIM domain)
  • N-terminal actin-targeting domain, facilitating ZNF185 binding to actin and necessary and sufficient to mediate actin-cytoskeleton targeting of ZNF185
  • LIM domain, localized in the C-terminus is dispensable for this phenomenon
  • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • zinc finger LIM protein
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    basic FUNCTION
  • regulating cellular proliferation and differentiation
  • may be involved in protein-protein interactions
  • actin-cytoskeleton-associated LIN11, ISL1, and MEC3(LIM) domain-containing protein that localizes to F-actin structures, and is enriched at focal adhesions
  • may function as a tumor-suppressor protein by associating with the actin-cytoskeleton
  • CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in prostate cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS