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FLASH GENE

Symbol

ZNF174

contributors: npt - updated : 07-05-2009

HGNC name	zinc finger protein 174
HGNC id	12963

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	16p13.3      Physical location : 3.451.189 - 3.459.362
Synonym name	zinc finger and SCAN domain-containing protein 8
Synonym symbol(s)	ZSCAN8, AW-1

DNA

TYPE	functioning gene
STRUCTURE	8.12 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Map

see MEFV

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 3 - 2498 46.3 407 - Williams (1995) variant 2 3 - 1593 26.7 234 - Williams (1995)

EXPRESSION

Type

constitutive of

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen           thymus         Cardiovascular heart         Digestive intestine small intestine         intestine large intestine colon     Endocrine pancreas         Nervous brain         Reproductive female system ovary         male system testis     moderately   male system prostate       Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Lymphoid         Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	C2H2 type, Krüppel-like, DNA binding protein
	a leucine rich region
	a SCAN domain found in the three zinc finger motifs, capable of mediating the dimerization of a large family of zinc-finger transcription factors

conjugated

MetalloP

mono polymer

homomer , dimer

HOMOLOGY

Homologene

FAMILY

krueppel C2H2-type zinc-finger protein family

CATEGORY

regulatory , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION

potential transcriptional repressor involved in regulation of transcription, DNA-dependent

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	Zn2+

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS