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FLASH GENE
Symbol ZNF146 contributors: mct - updated : 21-03-2009
HGNC name zinc finger protein 146
HGNC id 12931
Location 19q13.12      Physical location : 36.705.503 - 36.729.673
Synonym name
  • only zinc finger protein
  • zinc finger protein OZF
  • Synonym symbol(s) OZF, MGC125660, MGC125661
    DNA
    TYPE functioning gene
    STRUCTURE 24.17 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence cytosine-phosphate-guanine/HTF
    Binding site
    text structure one CpG island, several regulatory elements
    MAPPING cloned Y linked N status confirmed
    Physical map
    SNX26 19q13.13 sorting nexin 26 PRODH2 19q13.1 proline dehydrogenase (oxidase) 2 NPHS1 19q13.1 nephrosis 1, congenital, Finnish type (nephrin) KIRREL2 19q13.13 kin of IRRE like 2 (Drosophila) APLP1 19q13.1-q13.2 amyloid beta (A4) precursor-like protein 1 TA-NFKBH 19q13.13 T-cell activation NFKB-like protein HCST 19q13.1 hematopoietic cell signal transducer TYROBP 19q13.1 TYRO protein tyrosine kinase binding protein MGC2656 FLJ36445 19q13.13 hypothetical protein FLJ36445 MGC15677 19q13.13 hypothetical protein MGC15677 CLIPR-59 19q13.13 CLIP-170-related protein THAP8 19q13.13 THAP domain containing 8 FLJ33298 19q13.13 hypothetical protein FLJ33298 DKFZP434J046 LOC390925 POLR2I 19q12 polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa CKAP1 19q13.11-q13.12 cytoskeleton-associated protein 1 CAPNS1 19q13.13 calpain, small subunit 1 COX7A1 19q13.1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) FLJ36991 19q13.13 hypothetical protein FLJ36991 ZNF146 19q13.1 zinc finger protein 146 LOC388534 19 similar to Hypothetical zinc finger protein KIAA1559 MGC45380 19q13.13 hypothetical protein MGC45380 LOC126162 19q13.13 similar to peroxisomal acyl-CoA thioesterase 2B; likely ortholog of mouse peroxisomal acyl-CoA thioesterase 2B FLJ14779 19q13.13 hypothetical protein FLJ14779 LOC388535 19 LOC388535 LOC390926 19 similar to C-terminal binding protein 2 (CtBP2) LOC339324 19q13.13 hypothetical protein LOC339324 KIAA1615 ZNF382 19q13.13 zinc finger protein 382 GIOT-1 19q13.2 zinc finger protein 382
    RNA
    TRANSCRIPTS type messenger
    text Variants 1, 2, and 3 encode the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 3806 33.2 292 - 2005 15881673
    3 - 3765 33.2 292 - 2005 15881673
    4 - 3880 33.2 292 - 2005 15881673
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Nervousbrain   lowly
    Reproductivefemale systembreast   
    Respiratorylung   lowly
    Urinarykidney   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandular  
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    reproductivemammary gland
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • ten Krüppel-like zinc finger motifs
  • three zinc fingers at the C-terminus interact with a region of TERF2IP located downstream of the coil domain
  • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • transcription factor regulator
  • having a function that may be linked to telomere regulation
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    or overexpressed in pancreatic carcinoma and contributing to the progression of tumor
    tumoral     --over  
    in the majority of pancreatic cancers and in more than 80 p100 of colorectal cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    potential therapeutic target in colorectal cancer
    ANIMAL & CELL MODELS